Movie actress Christine Rapp hires Monk to protect her against a killer who is targeting her because of the tell-all book she wrote. Monk is eager to be with her since she was the child star in his favorite boyhood TV show, The Cooper Clan. However, he soon realizes that Christine isn't the innocent girl of the TV show... and that everything isn't what she claims.
Monk meets a visiting African widower who's determined to find the hit-and-run-driver who killed his wife near Monk's apartment. Monk begins to identify with the man and confuses his wife with Trudy.
While traveling, Monk and Natalie becomes involved with the death of a woman... who died in the desert after Monk sees a UFO.
When a hitman is run over by a bus, the FBI realize that he's an exact twin for Adrian Monk and ask the detective to learn who the killer was going after... by impersonating him.
Monk and the police have a killer right where they want him... until the case goes to court and a hotshot lawyer demolishes the prosecution.
When a critic pans Julie's community theater performance, Natalie thinks he's responsible for the death of a young woman who fell from the balcony of a nearby hotel.
Three San Franciscans die and it's discovered that postmarked voodoo dolls were sent to them several days before their deaths. Each doll predicted the victim's death. Monk and the police try to solve the crimes, only to discover that Natalie has received a voodoo doll predicting her death.
When Monk's HMO cuts him off, he is forced to join Dr. Bell's group sessions, where someone seems to be killing the patients.
While Monk investigates the mysterious death of an office building's maintenance man, Natalie tries to plan a surprise party for Monk's 50th birthday despite his refusal to cooperate.
Sharona comes to San Francisco to collect a settlement from a country club after her uncle accidentally fell to his death. However, Monk realizes that her uncle was murdered and begins an investigation, only to find himself caught in the middle when Natalie and Sharona argue over him.
When an artist disappears, Monk is called in to investigate. He adopts the woman's dog and grows closer to it, as he realizes that its mistress was murdered.
When one of three panel members refuses to reinstate Monk as a police detective, Adrian arranges to go on a camping trip with the man's son in the hopes he can schmooze his way back onto the force. Unfortunately, two armored car robbers have their money hidden near their camp.
Stottlemeyer proposes to the love of his life, but someone sets out to ruin his wedding.
Monk finally wins his reinstatement to the police force as a detective, but soon discovers that it's not all he might wish for.
When a killer connected to the mysterious "Judge" who ordered Trudy Monk's death murders a doctor at a midwife clinic, Monk is called in to solve the case. The Judge gets nervous and orders Monk's death by slow poison.
As he is dying of poison, Monk finds Trudy's last tape telling him what happened, and he must decide whether to seek revenge for his wife's murder.