After he is attacked and knocked unconscious by a man who claimed to have information on Trudy's death, Monk wakes up with amnesia in a small town. Without a dollar in his pocket, he wanders around town trying to remember who is, until he meets an eccentric woman who claims to be his wife. As Monk tries to adjust to his new life, he learns that a friendly waitress he met in a diner has disappeared. After a little bit of investigation, he is able to determine that she was murdered, but nobody in town will believe him. Meanwhile, back in San Francisco, Natalie, Stottlemeyer and Disher are frantically trying to piece together what happened in an attempt to locate Monk.