Jackie's back to using again, but she's doing it differently this time: maintaining a clean and sober cover, going to 12-step meetings - even finding herself a sponsor - all the while getting her drugs from the towel girl at the gym. Meanwhile at All Saints, Zoey finds out that everyone knows about her 'secret' relationship with Prentiss.
Jackie needs a new source, so she steals Dr. Roman's DEA number and calls in a prescription for herself. Back at All Saints, Carrie gets jealous when Coop is recruited by a 'sperm scout' because of his online dating profile. Later, out on a date with Frank, Jackie spies a hot, young hipster dealing and sneaks off to the bathroom with him.
Coop gets the crushing news that his sperm count is too low to allow him to donate. Carrie gets a lucky break, which leads to a medical segment on the local news. Akalitus is on a winning streak, too, with her poker habit starting to pay off. Jacki, however, gets blindsided when Grace - who's been arrested for shoplifting - drops a bomb.
Jackie is pressured by Frank to let him move in but she keeps putting him off and discovers a surprising secret about him. Coop and Carrie grow closer as she puts him on television.
Frank is convinced Jackie is hiding drugs in her house, however before he can find them, she stashes them in the ladies room at the hospital. Jackie finds comfort in a fellow drug user after she bonds with a homeless and alcoholic nun. Zoey encourages Prentiss to do what he wants.
Jackie's fake identity is compromised - but she's got more pressing problems to deal with: she's on her last bag of pills, Frank has just moved in, and her sponsor Antoinette is hounding her about her sobriety. Meanwhile, Prentiss plans a big night out with Zoey, but their date is cut short when she suspects that something is wrong.
Jackie is ambushed by Antoinette. Coop's dream finally comes true.
Jackie detoxes at home - with help. Frank raises an objection about Grace.
Jackie has to act quickly when she finds out she will have to provide a urine sample as part of a DEA investigation. Kevin and Mia begin making wedding plans. Coop and Carrie find a way of getting around their no sex in hospital rule.
Jackie and Frank breakup. Jackie realizes the only way she can continue to use drugs is by separating herself, from those closest to her. Carrie forgets Coop's 40th birthday. Zoey decides that she wants to be a nurse practitioner. The DEA's investigation continues.
Jackie heads to Kevin's wedding, reluctantly. Zoey witnesses Jackie nearly make a fatal error with a patient, at work. Carrie wants to meet Coop's mom. Akalitus feels pressured by the DEA.
Akalitus tells Jackie she has to admit that she's on drugs, or will have to take a test. Coop confronts Jackie, but she has surprising news for him.