Ratings: 2.21 million viewers

Special guest star James van der Beek (Dixon) previously starred on Dawson's Creek which was filmed in Wilmington, North Carolina, the same city as One Tree Hill.

Paul Johansson (Dan Scott), Antwon Tanner (Skills), and Barbara Alyn Woods (Deb Scott) do not appear in this episode.

Julian: (opening voiceover) A little old man and I fell out. I'll tell you what it was all about. He had money, and I had none. And that's the way the noise begun.

Jack: A lot of girls would do it with me.
Sam: Yeah, and those girls are called prostitutes.

Owen: You know, I haven't had a drink in over eight years. Tonight that's going to change.
Millicent: I haven't had sex in over 22 years. And tonight that's going to change.

Nathan: (voiceover during basketball tryouts) Numbers are funny. They can measure you, time you, and analyze you all they want, but they all know what really matters is how you play the game. He thinks I've lost a step because of my accident, so he's gonna play me tight. I haven't. Now he'll back off because he doesn't want to get beat off the dribble. Just a half step; that's a mistake. You ever hear the expression you can't measure heart? Well, the truth is they can't measure any of it: heart, want, need. They think I can't play point guard, but Q knew I could. You can't measure a dream.

Jamie: (closing voiceover) A man of words and not of deeds is like a garden full of weeds. And when the weeds begin to grow, it's like a garden full of snow. And when the snow begins to fall, it's like a bird upon the wall. And when the bird away does fly, it's like an eagle in the sky. And when the sky begins to roar, it's like a lion at the door. And when the door begins to crack, it's like a stick across your back. And when your back begins to smart, it's like a penknife in your heart. And when your heart begins to bleed, you're dead, and dead, and dead indeed.

During the beginning of the episode where Julian pours sugar on the table, the area where the sugar was poured changes between shots.

Episode Title: You Have Got to be Kidding Me (Autopsy of the Devil's Brain)

"You Have Got to be Kidding Me (Autopsy of the Devil's Brain)" is the title of a song by The Flaming Lips.

On Dawson's Creek, special guest star James Van Der Beek starred as Dawson Leery, the title character who dreamed of becoming a director, similar to his special guest star role as Dixon the director.

The nursery rhyme Jamie reads for the closing voiceover is the 17th century A Man of Words and Not of Deeds by John Fletcher.

The flashback to Brooke getting attacked is a reference back to "Touch Me I'm Going to Scream."

The flashback in which Quentin is fatally shot is a reference back to "One Million Billionth of a Millisecond on a Sunday Morning."