10 contestants are paired up in Los Angeles and given $2,500 and five days to use as charity and much do as much as possible to make a change in someone's life.
The nine remaining contestants have 48 hours to make the biggest change possible in a strangers life after being left off in an unfamiliar region.
Some 1,000 children await the arrival of the eight remaining contestants. Guests include tennis great Andre Agassi and skateboard legend Tony Hawk.
While in Miami, the remaining seven contestants have 24 hours to give away hundreds of thousands of dollars.
A contestant receives a "Big Give Road Test" challenge from driver Danica Patrick.
Two people have their last wish answered by the final four contestants with assistance from Jada Pinkett Smith and Natalie Cole in New York City.
After seven weeks on the road, Oprah sends the final three home to visit their families. This week, the contestants have four days and $10,000 in cash to prove that they have what it takes to win.
In the "Big Give" finale, Oprah presents the final challenge. With no money and little time, the remaining contestants must create a "big give" out of nothing at all. Meanwhile, Jennifer Aniston delivers big news.