Out of Practice is a comedy about a family of physicians who share the same profession but have little else in common. Ben Barnes is an earnest young couples' counselor whose family doesn't consider him to be a "real" doctor because he doesn't have "M.D." after his name. They're the real doctors: Ben's brother Oliver is good-looking, self-centered, and a plastic surgeon who enjoys dating the prettiest women in town, some of whom he helped make that way; and his sister Regina is an E.R. doctor who's hooked on the non-stop action there. Their divorcing parents are Stewart, a gastroenterologist who is glad to be free from the reins of his controlling wife, and Lydia, a driven, status conscious cardiologist whose career eclipsed her ex's years ago. Stewart is also dating Crystal, his assistant, who just happens to be a patient of Oliver's. But despite their lofty credentials, Ben might be the best prescription for the future of this family.
Valentine's Day becomes a disaster for the whole family when Lydia and Oliver almost end up in a romantic dinner, Regina treats her father at the hospital when he shows up with a back injury, Ben accidentally locks himself in Crystal's bathroom while she is taking a bath, and one of Ben's loser friends hits on Lydia.