Over There centers around members of a U.S. Army Unit deployed to Iraq for their first tour of duty. The series explores the effects that being in the center of a war has on soldiers fighting, as well as on their families back in America. Instead of exploring the politics behind the war, Over There focuses on the challenges, including physical, emotional, and cultural, that the soldiers experience while on tour in Iraq. Aside from being one of television's most graphic and violent shows in history, Over There was also the first scripted series to be set in a current, ongoing war in which the United States is involved.

A week after the last episode aired, FX announced that the series would not be picked up for a second season due to a significant drop in ratings.