In the series premiere a new school year begins at Kennedy High, where the battle begins between the popular crowd (Brooke, Nicole, Josh, and Sugar Daddy) and the unpopular crowd (Sam, Harrison, Lily, and Carmen).
Brooke throws a beginning of the year party that is crashed by Sam and her friends.
Sam and her mother come over to Brooke's house to try out a 'family dinner' scenario. Meanwhile, Mr. Vincent takes some unusual measures to get back at the football coach while fighting over Josh Ford, who is simultaneously starring in Mr. Vincent's play and being quarterback of the football team.
A rumor goes through the school that Brooke and Josh haven't actually 'done it.' Lily starts a new job at a chicken fast-food restaurant.
Carmen throws a sweet 16 slumber party, which the popular girls crash for dishonorable intentions. Carmen realizes who her real friends are.
The tension between Brooke and Sam reaches a breaking point when a food-fight breaks out in the school cafeteria.
The Homecoming Queen race becomes nasty. Mary Cherry's mother tries to run her daughter's campaign by slandering Brooke.
Carmen and Sugar Daddy both enter internet relationships; Brooke and Josh take their relationship to the next step; and Sam convinces Carmen's brother to pretend to be her boyfriend, all while a new hit song breaks out through the campus.
Harrison's mother has a huge surprise for him.
It's Christmas time and the kids re-enact 'A Christmas Carol' with Nicole in the role of Scrooge.
Carmen, finding new popularity with her new status as a cheerleader, is pressured by the popular girls to dump her old friends.
When Emory Dick fails his biology midterm he decides to sue the school because he believes that his harassment by various people in the school has led to his position.
The Sadie Hawkins dance mixes up the girls and the boys.
A wicked game of 'truth' interrupts when the girls find themselves locked in the girls' bathroom for the night.
All the kids somehow find themselves subjected to Principal Hall's Boot Camp weekend detention.
The new guy tries to become the school's first male cheerleader.
Brooke and Carmen fight over Josh, while all the other girls are preoccupied with the school's new hunky vice-principal.
Harrison stages a sit-in to help save the job of the school's shop teacher when he announces that he is undergoing a sex-change operation.
Lily fights for the rights of a lobster; a new girl comes to town and sparks a competition between the blondes vs. the brunettes.
The wedding Sam and Brooke have been dreading is quickly approaching.
Brooke's plan to throw her father a bachelor party backfires horribly.
Tired of the special 'sweeps' episodes that happens during the end of the TV season on their favorite shows, Mary Cherry and Nicole try to satire the different season finale devices; two weddings and a funeral occur.
The new school year begins at Kennedy High, but the memories of the called-off wedding are still in recent memory. Sam has to deal with Brooke's mother's return, but Brooke has a hard time dealing with differences between herself and her mother. Meanwhile, Ms. Glass makes her shocking return to Kennedy High; Carmen receives news about her pregnancy; Sugar Daddy and Lily take part in a protest to save an old tree; and Nicole has Mary Cherry try out for the Glamazons.
Ms. Glass gives the students an assignment: everyone must take care of a "Baby, Don't Do It" doll. However, everyone has other ideas. Lily and Carmen partner up for the project, but differences in cliques strain the working partnership. Nicole and Mary Cherry give their doll to a nanny to raise, but find that passing the responsibility off was not the best idea.
Brooke strikes up an unlikely friendship with Bonnie, the SAT teacher. However, the two end up in trouble with the law. Carmen's life is thrown off balance when she asks Sam to move in, but Sam soon sees that Carmen is hiding a painful secret.
A new student, George Austin, arrives at Kennedy High, and his arrival cause strain for both Josh and Sam. Josh worries that George will overtake his status as star football player and Sam believes that George is just your typical jock and nothing more. Meanwhile, Nicole decides to regain her Glamazon status.
Ms. Glass uses the students for her own social experiment and pairs each one up with another. However, this assignment causes problems between Harrison and Nicole when Harrison is jealous of George and Sam striking up a friendship and Nicole worries that Brooke and Josh's relationship will demote their popular status.
Brooke and Harrison go head to head in the student-council president elections, while Sam gets lost in the glit and glamor of being nominated for homecoming queen. What's wrong with this picture?
Nicole and Mary Cherry try to sabotage Carmen's homecoming queen campaign while Harrison continues his fight against the random drug tests. What is he hiding?
Mary Cherry hires Sam to ghostwrite her memoirs as a payback for her mother's soon-to-be-published book which describes Mary Cherry as the "gunk in the bucket after a liposuction". Harrison checks in at the hospital to start chemotherapy and has a brutally revealing encounter with Brooke, causing her to binge out on chocolates.
Josh and Lily land roles in the school play and are required to appear nude, which creates quite a bit of discomfort between them. Meanwhile, Brooke heads back to the hospital for anorexia treatment.
Harrison is deeply impacted when Clarence dies while talking to him, and contemplates suicide as means to deal with his emotional agony. However, when Clarence returns as an angel, he gives Harrison a glimpse into what the future would be like without him in it.
It's once again STD Awareness Week and Ms. Glass makes it a memorable one by writing and performing a musical entitled "That Burning Sensation" and each student is assigned a disease to portray.
Harrison returns to school following his bone marrow transplant, but acts differently than before causing people to think that he has become possessed. Meanwhile, Sugar Daddy is jealous when Josh spends all of his time with Lily.
Mary Cherry gets a glimpse of real life when she learns her family is having money problems. Meanwhile, Sam and Carmen work to bring back the school yearbook and Brooke and Harrison's relationship future is on shaky ground when it appears that Harrison wants to be with someone else.
Tragedy hits Kennedy High and the news of the death of April Tuna affects each of the student's lives. Brooke, Mary Cherry and Carmen all think that they are responsible while Lily and Josh believe they are to blame because they excluded her from their circle of friends.
Bored with their lives as high school students, Brooke meets a girl in college who invites everyone to a college party. Sam and Lily try to sneak out to the party, but end up stuck at home for lying. After bad experiences at college all around, both the boys and the girls realize that high school isn't so bad after all.
In an attempt to reach out to students who have been teased due to their lifestyle, Lily founds G.L.A.S.S.: Gay and Lesbian Alliance of Supportive Students. This new club gets everyone talking, but it doesn't get the reception that Lily had hoped.
Principal Krupps has April Tuna choose one of the school's clubs to cut. Nicole uses the opportunity to manipulate April into cutting the Glamazons. Meanwhile, Brooke lands herself in hot-water after not coming home from Jamie's.
Mary Cherry puts together a team to compete in a local academic-challenge program on cable access television in hopes that being on television will get her discovered. Meanwhile, Mary's mother, Cherry Cherry, enrolls at Kennedy High when she learns her low SAT scores are keeping her from joining a ritzy country club.
All Kennedy High students are placed under quarantine when Harrison comes down with symptoms of an exotic disease everyone believes he caught while on spring break in Yemen.
Sam and Brooke decide to give Harrison the silent treatment when they realize he's been leading them both on. Meanwhile, Josh learns that his mother landed a job in another state, which means they will be moving.
In the series finale, Nicole asks Harrison to the junior prom, but both Sam and Brooke ask them to go with them as well. Meanwhile, Mary Cherry meets a girl who says she is her long-lost sister.