Michael uncovers unbelievable news in Los Angeles when he seeks revenge against Whistler and Gretchen for Sara’s death. Michael and Lincoln are reunited with the gang and receive an offer from a Homeland Security Agent they cannot refuse. Mahone suffers a devastating loss, and T-Bag is deserted during his flight to freedom.
Michael, Lincoln, Sara and the team work with Roland, a new team meber, to get a copy of the data card. Meanwhile, Wyatt continues his mission to track down the brothers while T-Bag makes his way north using the bird book as his guide.
Michael and the team have one day to find the next cardholder or they risk going back to prison. Mahone seeks revenge on Wyatt who is attempting to extract info on Sara’s whereabouts, while T-Bag finds the gateway to his new identity and future.
Michael, Lincoln and Sucre must crash a police benefit to obtain the next card key. Reeling from another death, Sarah falls back into an old habit. T-Bag arouses suspicion and runs into some old “friends” his first day on the job.
Michael and Lincoln make their way to the Treasury Department in search of the next key card holder; an awkward alliance formed by T-Bag at his new job arouses the suspicions of Sucre and Bellick; Wyatt uses his magic touch on Gretchen.
Michael and the team tracks a key card holder to a racetrack; Mahone gets caught with something priceless; Wyatt targets Agent Self; T-Bag starts to figure out Whistler's code.
Lincoln takes members of the team to Las Vegas where Sucre gets an indecent proposal. Sarah learns about Michael’s condition, and Roland pushes his luck too far. Gretchen teams up with T-Bag who makes an offer to Michael he cannot refuse.
Meanwhile, the secrets in Whistler’s bird book are finally revealed.
Songs: The Bravery -- Believe (Moon Version)
Lincoln hatches a plan to get the final card from the General. Meanwhile, Michael and Self must work with Gretchen and the group continues to harass Roland for losing the device in Vegas.
Wyatt gets a taste of his own medicine, and Mahone finds some resolution. T-Bag scrambles when the police investigate his missing co-worker while Gretchen gets cozy with a Company man.
Michael’s condition continues to worsen, and a team member makes the ultimate sacrifice while planning the underground break-in for Scylla.
When Michael's condition begins to worsen, Sara has no choice but to take him to the emergency room. Later, Sara receives a shocking call about Michael's ailment. Meanwhile, Sucre and Lincoln find themselves in explosive territory; Agent Self makes a surprising ally; and Mahone is able to track down vital information about Scylla.
Michael and the team find themselves in a race against time, but Michael's deteriorating condition forces Sucre to take the lead in the break-in. Meanwhile, Gretchen tries to get the last key card from the General, and T-Bag is faced with a decision that could take him away from his criminal life for good.
As the search for Scylla comes to a surprising end, Sarah takes a hostage, T-Bag and Gretchen have their last stand at Gate, and Michael and Lincoln are betrayed by one of their own as they finally get to go face-to-face with the General.
It's up to Michael to hold the gang together after they find out they were betrayed by one of their own. Meanwhile, Gretchen is blackmailed by T-Bag's new partner.
Michael and Lincoln work to get Scylla back from Gretchen and her new partner. Meanwhile, Mahone meets up with an old colleague, and T-Bag is put to the test.
Michael gets medical attention from the most unlikely of places, and Westmoreland returns to help uncover the true meaning of Scylla. Meanwhile, Lincoln and Sucre race to stop Gretchen before Scylla is lost forever.
Lincoln and his new partners arrive in Miami to recover Scylla from its shocking new owner, and Sara searches for a missing Michael who learns some surprising information about his past. Meanwhile, a double-crossing leads to a death and an arrest.
Michael and Sarah learn the dangers of hitchhiking as they make their way to Miami, and Lincoln meets with Christina who informs him of her plans to take over the Company.Meanwhile, Pad Man feels the heat from an new enemy, and T-Bag and Self’s search for Scylla leads to an unexpected discovery.
Michael and Lincoln square-off over Scylla as Christina orders a kill shot and set sets her plan in motion. Sarah receives some unexpected news, T-Bag causes a scene at the Indian Embassy and Pad Man’s paranoia leads to a death.
Michael has an uneasy reunion with Christina, who drops a bombshell regarding Lincoln. Lincoln races to stop Christina’s deadly master plan. T-Bag must prove he is a Company man.
Pandemonium erupts at the hotel following the assassination, and Christina puts the final pieces of her plan together. Meanwhile, the General makes good on his threat, and Michael is forced to choose between saving either Lincoln or Sara.
Familiar faces return to help Michael end his quest to bring down The Company once and for all.