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Picking up eight hours after their escape from Fox River, Michael, Lincoln, Sucre, Abruzzi and C-Note are on the run for their lives as a vengeful Bellick leads the prison guards seeking to capture their escaped quarry; Dr. Sara is in critical condition from her overdose; Veronica finds herself a prisoner with Terrance; T-Bag tries to get the upper hand while fleeing from the authorities; and a new take-charge FBI investigator proves to be Scofield's match.
C-Note: We need to go east, my family's back in Chicago!
Abruzzi: Think the cops don't know about it? You think they're not just sitting there waiting for you to come running back home? What's the matter with you?
Sucre: What about New York?
Abruzzi: What about it?
Sucre: My girl’s pregnant, bro!
Abruzzi: Understand your love is your weakness right now, and they know about it.
Michael: Doesn't mean it has to stop you. Just gotta be smart about it.
Lincoln: You really think the money is gonna be there?
Michael: Charles might have had a flexible relationship with the truth, but at the end...at the end there'd be no reason for him to lie about it.
C-Note: Don't think I don't know where you were going either, Scofield.
Michael: Where am I going?
C-Note: Oh, I don't know, Utah? When were you plannin' on tellin' us about the money?
Sucre: What money?
C-Note: Five million dollars that Westmorland planted in the desert in Utah.
Michael: You don't know what you're talking about.
C-Note: You wish I didn't know.
Agent: It's not like they left us a map where they're going.
Mahone: Actually, that's exactly what they did.
Mahone: (In Scofield's apartment) So this is where Scofield lived?
Agent: Yeah, up until about 2 months ago when he was incarcerated.
Mahone: Mothers dead... Fathers a dead beat. Got nothing in the whole world but your brother. So you planned and you scheme for months until you get it right. Every single element and then you destroy all the evidence.
(Walks over to the window and looks down) I want divers in the river.