In the town of Coeur d’Coeur, 9-year-old Ned is playing with his dog Digby. Digby runs in front of a truck and is killed. When the curious Ned reaches out to touch his dog… it comes back to life. Happy and reunited, the two run off to continue playing... unaware that nearby a squirrel has fallen out of a tree, dead.
Later, Ned experiments with his newfound abilities, touching a dead fly and bringing it back to life. He then watches his next-door neighbor Charlotte Charles (“Chuck”), who is pretending to be a dinosaur and who he has a crush on. Meanwhile, his mother is making pies but falls down dead of a stroke in front of him. He touches her and brings her back to life, and she doesn’t realize anything is wrong. However, a minute later Chuck’s father falls over dead. Ned figures out that if he keeps someone alive more than 60 seconds, then someone else in the vicinity has to die. Worse, when his mother tucks him in that night, she touches him and she dies again. Worst of all, Ned can’t bring her back to life a second time.
After their parents’ respective funerals, Ned’s father sends him to boys’ school while Chuck’s two aunts Lily and Vivian take her in. The aunts are retired synchronized swimmers. Who have escaped the outside world and are holed up in their house. Ned and Chuck share one kiss at the funeral before being separated.
Now, Ned is a pie maker like his mother, saving expenses by bringing dead and rotting fruit back to life. He runs a store, the Pie Hole, and waitress Olive Snook works for him. Ned works for private detective Emerson Cod, who was chasing a criminal that Ned accidentally brought back to life and then killed again. Ned and Emerson work together: Ned brings back murder victims and then uses his 60 seconds to find out how they died, letting them solve the cases and sharing the reward.
Emerson has a new case: a dog apparently mauled its owner but the family believes it’s innocent. They go to the morgue and Ned resurrects the victim, Leo. He reveals that his secretary used her own dog to kill him for revenge then framed his dog.
Olive is taking care of Digby, which Ned has avoided touching ever since he brought him back to life. Ned has avoided touching people, making Olive unhappy since she has a crush on him. Back at the Pie Hole, Ned spots a news broadcast about the drowning death of a woman on an ocean voyage. He catches the name and realizes that it’s a grown-up Chuck.
The travel agency that set up Chuck’s trip has offered a $50,000 reward so Emerson takes the case and they go back to the funeral home at Coeur d’Coeur. Ned gets a moment alone with Chuck’s corpse and brings her back to life. However, all she can reveal is that she was strangled to death with a plastic bag and never saw her killer’s face. Ned prepares to give her one last kiss before the sixty seconds run out... but can’t bring himself to do it. The funeral director is nearby and dies as a result. Ned closes Chuck up in the coffin and then goes outside acting innocent, but Emerson figures something is wrong. Ned ditches him and then follows the coffin to the cemetery. Meanwhile, Chuck remembers how she was tired of being locked up at her aunts’ house with nothing but her bees for company, and finally went on a trip just to get out on her own.
At the cemetery, Ned manages to get to the coffin and release Chuck, then takes her to his apartment since everyone thinks she’s still dead. She realizes something is wrong when she catches a newscast about her death and thinks Ned just brought her back for the reward. Ned manages to convince her that isn’t the case and asks her to stay there. She ignores him and goes out, running into Olive (who lives next door). Olive wonders who the new woman staying at Ned’s apartment is. At the Pie Hole, Ned is going over the case with Emerson with Olive and Chuck come in, and Emerson immediately figures out what Ned did. Chuck insists on becoming a partner in their operation and helping out, then reveals that the travel agency owner, DeeDee, gave her a discount on the trip in return for her delivering two plaster monkeys.
They go to the travel agency and find DeeDee dead, suffocated with a plastic bag. Ned brings her back to life but DeeDee touches him and ends up dead before she can say anything about the monkeys or her killer. They figure out she doesn’t have the monkeys and they were sent to Chuck’s next-of-kin: Lily and Vivian. The killer has also figured it out and arrives at the aunts’ house.
Chuck has to stay in the car to avoid her aunts (who think she’s dead), while Ned and Emerson go in. It turns out that the aunts’ famous synchronized swimming mermaid act came to an abrupt end when Lily got dirty cat litter in her eye. The subsequent loss of depth perception forced them to quit, and they went into isolation. Ned and Emerson talk to the aunts, while Chuck goes around the back to check up on her bees. She then climbs up to her second-story room and finds the monkeys. Lily comes in to get them and Chuck hides, only to see the killer go after her aunt.
Ned runs upstairs and the killer attacks him, but Chuck helps him out. Lily isn’t really dead: her training as a synchronized swimmer let her hold her breath and survive. She shoots the killer with a shotgun, blasting him out the window where he falls to his death. Because she only has one eye, she doesn’t see Chuck off to the side, and her niece slips quietly away.
Later, Ned admits he was being selfish about keeping Chuck alive, but still covers up the fact that he killed her father. They share a kiss by touching the monkey statues’ lips together... then realize they’re too heavy. Smashing them open, they find that DeeDee was smuggling gold. The aunts get the reward since they now own the monkeys, and prepare to leave their home for the first time in years.
Ned, Chuck, and Emerson take on a new case, of a scuba diver who drowned in a restaurant lobster tank. Chuck gets involved for the first time... and asks if the dead man has any last words or wishes. Ned and Chuck end up holding their own hands... and pretending they’re holding each other’s.
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