The series begins with a look at the lives of the four Sorelli sisters. Ginnie, the oldest sister and an attorney, has to tell her husband that she's pregnant, but can't decide on a way to do so. Anne has to face the fact that her relationship with Danny may be over. Marjee has to find the perfect restaurant to host Jillian Barbaree's Pug Dog Benefit, but has trouble doing so. Rose, the youngest of the sisters, has to break the news that she's changing majors from Pre-Med to Experimental Theatre. Meanwhile, the girls' father, Joe Sorelli, announces that he's going to marry Renee, his current girlfriend.
Now that Ginnie has told Bob about being pregnant, they decide to act like tourists and make a list of all the things they want to do in New York before they're parents. Marjee is having a hard time dealing with Renee when both her and Renee move in with Joe. Anne, meanwhile, has to deal with her break-up and Rose falls for a classmate in her acting class.
Longview -- Can't Explain, Citizen Cope
-- Son's Gonna Rise
With Anne still dealing with her break up with Danny, Ginnie gives her some sisterly advice to talk to Danny, but Anne reacts badly to it. Marjee considers quitting after being at odds with her boss. Meanwhile, Rose clashes with a classmate who makes fun of Rose in one of her monologues. Rose tries to find a way to get rid of the girl, but can't find one.
When Joe goes out of town, the sisters offer to help run the deli for him. Things get out of control when Marjee throws a party at the house and Anne realizes her feelings for an old childhood friend.
Parachute Express -- Clean Up Crew, Rihanna
-- Pon de Replay
Ginnie and Bob have to not have sex for a few weeks as a precaution. Rose continues to fall hard for Alex, and has to decide whether or not to have sex with him. Marjee is put in an awkward situation when she has to plan a wedding with Jason, her boss's boyfriend who Marjee made out with. Meanwhile, Anne sleeps with one of Rose's classmates.
With a family Thanksgiving planned in Ginnie and Bob's loft, Ginnie, Anne, Marjee and Rose cook a traditional Sorelli dinner using all of their mother Francesca's favorite recipes and can't help but reminisce about their memories of her. Meanwhile, Anne is frustrated over her feelings for Rose's classmate, Zach, a guy she slept with in a moment of weakness, but is inarguably very much attracted to; and Renee is rushed to the hospital with a stress-induced asthma attack after Ginnie blows up at her.
Bob returns the car that he bought for Ginnie, but soon after, Ginnie decides she wants it back and will have Marjee teach her how to drive. Rose and Alex's relationship is thrown off track when Alex asks Rose if Joel has feelings for her. Anne gets more than she bargained for when Renee lets Anne in on her big secret but asks her not to tell Joe.
Now that Christmas break is over, Rose must choose once and for all who she wants to be with, but has a hard time doing so. Marjee gives Jason an ultimatum while Anne continues her affair with Rose's classmate, Zach. Meanwhile, Ginnie and Bob meet with an attorney to draw up a will, but their different views make the task hard.
Though knowing that she hurt Joel's feelings, Rose continues her relationship with Alex and considers having sex with him. Ginnie becomes angry at Bob when she learns that he's been hiding the fact that he's producing an album for an ex-girlfriend. Meanwhile, Anne asks Danny to give Marco advice on running his sausage business and Marjee has trouble dealing with her feelings for Jason, especially since he has yet to tell Trish about their affair.
Bob's ex-girlfriend, Kylie, stays at Ginnie and Bob's loft. Her presence makes Ginnie feel more and more jealous and Ginnie begins to wonder why Bob wants her to stay. Rose invites Alex to dinner, but Joe's behavior surprises Rose. Meanwhile, Anne and Marjee talk about their romantic problems with Marco and Jason.
When Ginnie is unable to attend her father's wedding because she is put on bed rest, Bob comes up with a way for Ginnie to be able to be at the wedding without leaving her bed. Danny attends the wedding after encouragement from Anne, despite Anne bringing Marco as her date. Meanwhile, Rose and Alex audition to be extras in an upcoming movie.
Ginnie's pregnancy complications get worse and worse. At the hospital, Ginnie and Bob become scared as they face the reality of the problems. Meanwhile, Anne and Danny talk about their hook-up at the wedding, and Jason and Joel come to the hospital to comfort Marjee and Rose.
Songs: Tina Dico -- Long Goodbye
Ginnie, still suffering from the loss of their baby, continues to further herself from Bob, who tries to cheer her up by planning a romantic anniversary dinner. Rose and Joel try to restart their friendship, but Joel's girlfriend, Chloe, doesn't want them to be closer. Marjee and Jason's new business ends up landing one of Trish's biggest clients, but they soon find out that Trish had their company blacklisted. Meanwhile, one of Anne's secrets from the past is revealed, and Danny has to decide whether or not he can get past it.
Songs: Holly Brook -- Like Blood, Like Honey
Joe invites Ginnie and Bob to spend a weekend with him at the cape, giving them a chance to mend their marital problems. Trish kicks Jason out of his apartment so Marjee invites him to move into Anne's with her. Meanwhile, Rose kisses Joel in front of his girlfriend and Joe gives Ginnie and Bob some startling news.
Songs: Holly Brook -- Saturday
The sisters help Joe and Renee move to their new home at the Cape. While packing, they talk about their mother, leading to shocking secrets about her past being revealed. Bob has to decide whether or not to go on a business trip or stay with Ginnie in hopes of restoring their marriage. Marjee wonders if she made the right decision after she moves in with Jason, while Anne wonders if she's okay with never getting back together with Danny. Meanwhile, Rose decides to go after Joel when she realizes her true feelings for him.
Songs: Holly Brook -- Curious