A fast talker persuades Holden to transport a group of pioneers to some new land they recently purchased from him.
When the Enterprise is impounded, Grey has to sell a partnership to master pilot Bill Blake. However, both men soon end up having to get a local sheriff's cooperation by offering him a trip on President Zachary Taylor's inaugural voyage. And to pull that off, they'll need to shanghai the contract--and the President-- from a rival captain, "Bloodhead" Morgan.
Holden discovers that a young girl that he assumes wants a casual relationship with him is actually in shock over the death of her fiancé. She believes that Grey is her lost love and brings Grey home to her village in the swamps. The villagers are more than willing to keep Grey there to keep her happy.
An old friend of Grey's, Gentleman Dan Muldoon, bets heavily that his boxer, The Dublin Boy, can win. But when Dan discovers that Dublin Boy has a glass jaw, he has to go into the fight himself. When Grey discovers that the next punch will blind Dan, he ties up Dan and goes in himself.
When the Enterprise collides with a railroad trestle, Holden brings suit for damages and ends up facing a young attorney named Abraham Lincoln in court.
Holden rescues two shipwrecked actors then books them as the entertainment aboard the Enterprise.
Grey and Bill unwittingly book two feuding families as passengers on board the Enterprise.
Grey will gain a profitable cargo of cotton for the Enterprise if he can lure a conniving damsel away from a wealthy planter's son. He refuses to compromise his principles, but the woman convinces him to play along, hoping to make the son jealous so he'll stand up to his father and marry her.
An Army sergeant illegally shanghais an Enterprise crewman. When Grey confronts him, the sergeant has no choice but to shanghai him as well... and break him until he agrees to serve.
A gang of Mexican banditos takes over the Enterprise and their power-mad generale loads the Enterprise up with a cargo of stolen gunpowder and turns the riverboat into a bomb to use against his enemies.
The beautiful wife of a plantation owner tries to convince Grey to ship their cotton, breaking the monopoly of a greedy local businessman. However, the owner considers himself honorbound to abide by his debts, and his wife refuses to compromise for fear of losing her family lands.
In a case of mistaken identity, three prisoners abduct Bill, thinking he's the son of a dying fourth prisoner who can lead them to $100,000 in stolen money.
A showman wants the Enterprise to take his troupe to New Orleans but he doesn't have any money for passage. Grey agrees once he's convinced that the showman's lead singer will bring in enough money to cover the showman's IOU. However, when the singer's necklace is stolen, she refuses to perform unless Grey finds it.