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When a beautiful woman staggers into the street and collapses from an apparent overdose, Andy and Marlo chase down her dealer, tackling him in a cloud of powdered heroin. The arrest sends 15 Division into emergency response mode when the drugs prove to be laced with deadly bacteria. Led by Swarek, the troops scramble to get the contaminated heroin off the streets before a deadly outbreak sweeps through the city. Andy and Marlo are plunged into an awkwardly intimate decontamination process, forcing Marlo to expose a shocking secret. Meanwhile, Dov and Chloe comfort a man whose wife has fallen victim to the dirty drugs, and their budding romance is threatened when Dov suspects Chloe of harboring a dark secret.