Broadway sensation Arlene Sims suddenly breaks off her career to return to her hometown of Butte, Montana. Arlene is dying of a rare disease and has come home to spend her final days. But she didn't count on meeting Buz Murdock, who becomes smitten with her. As their relationship grows, Buz contemplates marriage, blissfully unaware that Arelene's time is running out.
To save the life of a wild stallion named "Blue Murder", who has been determined to be too dangerous to be allowed to live, Tod and Buz pledge to personally deliver the horse to rancher Jim Bludge in rural Montana. But when Bludge is found trampled to death, Tod is wracked with guilt and vows to hunt down and kill the animal himself.
In Pittsburgh, Tod and Buz befriend ailing elderly former blues singer Jennie Henderson. They then set out to fulfill Jennie's dying request: to reunite the members of her old combo for one final performance.
On the streets of Boston, Tod and Buz encounter Arnie- a heroin addict in the throes of withdrawal. Tod wants to help the man. However Buz, who has had one too many experiences with junkies in his past, vehemently disagrees - Arnie's case is hopeless, he says, and not worth their time. Tod is puzzled at his usually altruistic close friend's sudden coldness, and wonders at its real cause.
Once again in Cleveland, Tod and Buz become part of the Polish blue collar community. Their boss Jack Kolodziedjczak's greatest pride is his son Janosh, whom he is grooming to be a doctor. But tragedy strikes when Janosh's girlfriend Terry , the daughter of Jack's best friend Mike Palinski is found dead at the bottom of a ravine. With Janosh on the lam, Jack vows to avenge Terry's death, even if it means killing his own beloved son.
Tod and Buz are working in the Adams shipyards in Massachusetts. With the sudden death of the owner, socialite and heiress Prudence Adams arrives for the funeral and to take charge of her father's business. A romance develops between Tod and Prudence, which develops into something serious very quickly. Are there wedding bells in Tod's future?
All his life, Buz has wondered about the mother who abandoned him when he was an infant to live out an orphaned childhood. Now in the small town of Hester, Maryland, Buz has discovered a family - the Colbys - who look like they could be his brothers and sisters. With Tod and a tiny faded photograph, Buz starts on a quest through the streets of Baltimore to find the woman who may be his real mother.
Lillian Aldrich is trying to fit back into society after spending the last eighteen years in a mental hospital. On her first day back at work, she gets into an argument with Buz, who is unaware of her condition. When Lillian flees the office in tears, Tod and Buz learn of the situation. They resolve to help Lillian in her readjustment to normal life and to seek out the daughter who believes her to be dead.
In Pittsburgh, Tod finds himself enamored of lounge singer Perette Dijon. However, Perette is a beautiful princess locked up in a tower - the Mariott Hotel overlooking the city - and the dragon who guards her is her intensely jealous and possessive manager Glenn Ryan. When Tod attempts to court Perette, Ryan knocks him cold with a karate chop. Tod vows revenge and plans for a final showdown with Ryan in his aerie.
In Carlisle, Pennsylvania, Tod and Buz encounter traveling beauty contest promoter Max Coyne and are enlisted by him to help stage his latest competition in that town. However, when the community leans that Coyne is a fraud and a con man, our two young heroes may wind up in jail along with him.
Tod and Buz attend a party at a Philadelphia hotel. A misguided prank pulled by a pair of college boys results in Tod drinking a beer that has been spiked with a powerful, experimental hallucinogen. Tod flees the hotel and goes on a one-man rampage through the city as the effects of the drug cause him to experience extreme emotions and sensations: fear, rage, elation, paranoia. Buz and the Philadelphia police force must find Tod before the final phase of the drug takes place - Tod will enter a state of extreme depression in which it is certain he will attempt to take his own life.
In Philadelphia, Tod and Buz pay a visit to Chuck Brennan, a social worker who was instrumental in helping Buz escape a life of juvenile delinquincy as a youth. Brennan continues to work with street gangs, and accepts the challenge of a local gang leader named Packy to a dare game played on the rooftops of the city's apartment buildings. Brennan is killed during the contest, and it falls on Tod, Buz and the gang's reformed former leader Johnny to bring down Packy.
In rural Pennsylvania, Tod and Buz work for the Bracks, a wealthy family led by the domineering widow Agnes. Another widow enters the picture, Agnes' daughter-in-law Julie, who comes overseas from Europe bearing Agnes' grandson. When the family treats her arrival with open coldness and hostility, Tod and Buz are left as the only ones in town who seem willing to offer the young woman hospitality.
Touring historical monuments in Boston, Tod and Buz meet John Westerbrook, an eccentric yet distinguished man who displays a strong patriotism and travels with a small contingent of bodyguards. The boys later learn that Westerbrook is the head of a white supremacist organization. Boston police enlist the aid of our two leads, as Tod works inside the organization and Buz outside. The race is against time, as Westerbrook's organization seems about to be planning something which will result in the deaths of many innoncents.
Tod and Buz pick up work when the traveling rodeo comes to Mesquite, Texas. They come to the rescue of rodeo clown Ollie Crump from hazing at the hands of the outfits cowboys. Ollie is a former rider whose injury has led him to become a clown, and nurses a secret love for alcoholic trick rider Babe Hunter.
Framed for a crime he didn't commit, David Job returns home to his small Texas town following a five-year prison stint. He takes complete control of the town and kidnaps lead citizen Bob Harcourt , the man responsible for his frame-up. David intends to convene a kangaroo court in the local courthouse to pass judgement on Harcourt. Among the enforced participants in the trial are passerbys Tod and Buz.
Tod and Buz are working at a Long Beach veterans hospital. This brings them into the life of Frank Madera, a paraplegic who has been embittered ever since his wife left him, and Lori Barton, the nurse who loves him.
Tod and Buz arrive in Tucson, Arizona, at the same time as Vicki Russell, a free-spirited motorcyclist. Vicki manages to get herself tossed in jail within minutes of coming to town. Buz is fascinated by the young girl's cavalier approach to life and existence and springs for her bail, against Tod's better judgement. However, it is Tod who later falls under Vicki's spell and goes on a joyride with her into the Arizona desert.
In Dallas, Buz is kidnapped by Caine, a religious fanatic who has left a trail of dead bodies across the major cities of the United States. Caine wants the entire city to abstain from sin for twenty-four hours . . . or else Buz will become his latest victim.
Tod and Buz are working as day laborers for a Scottsdale, Arizona, development firm. When the company seeks a new vice president, Terry Prentiss promotes Buz to that executive position as part of a power play to demonstrate to her boss Lee Fisk that a woman can be a corporate executive. Buz, suddenly finding himself in high-rolling executive boardroom meetings, becomes Terry's puppet in this comedy of errors.
In Phoenix, Tod and Buz befriend their employer Carl Selman. When Carl is killed in a senseless mugging, the boys must come to the emotional rescue of his young son Davey, who has a crisis of faith on the verge of his Bar Mitzvah.
When he was an undergraduate at Yale, Tod had a crush on a dancer named Rosemarie Brown. Years later, Rosemarie has fallen on hard times, having just been widowed by an alcoholic husband. Tod and Buz, working for a Hollywood TV station, urge Rosemarie to audition for a dance troupe for one of their shows as a means to get her back on her feet.
Tod is hired for a special assignment - to be the special assistant to speed boat motor designer Sandy Mason. The demands of this driven man who is on the verge of a revolutionary breakthrough in engine design keep Tod working overtime. But when Mason's prodigal daughter arrives on the scene, Tod finds himself drawn just as intensely into the man's personal life as well as his professional.
Buz is knocked out during a construction work accident, and when he regains consciousness he finds that he is unable to see! A doctor tells him his loss of vision may be temporary, or it may be permanent. Buz first contemplates taking his own life, but then agrees to enroll in a Texas institute for the blind so that he can retrain himself to live in society. Buz is assigned a young blind woman as his teacher, and as he gradually begins to cope with both his blindness and becoming part of the world again he begins to fall in love with the young woman. This episode marks one of George Maharis' most memorable performances of the series.
Tod and Buz are stopping over for lunch in a sleepy little Texas town. Suddenly, a bus pulls into town, and one of the passengers who disembarks is a young woman who is wearing a hideously frightful mask. The girl's purpose for arriving thus costumed seems to be part of a mysterious vedetta against the town. Unable to resist the lure of this mystery, Tod and Buz attempt to gain the confidence of the woman to find out who she is and the purpose behind her arrival.
After stopping to help a young woman with car trouble, Tod and Buz find themselves part of a kidnapping. They soon learn that the woman is the daughter of famed embezzler and international fugitive Charles Clayton. Clayton has risked recapture to come back to the United States to visit his daughter.
While working as deckhands on a Cleveland river tour ferry, Tod and Buz come to the rescue when a young boy goes off the boat into the water. The boy, Richie McIntyre turns out to be the son of local business tycoon Willard McIntyre, and claims that he did not fall overboard, but was pushed. Then the elder Mcintyre begins receiving threatening notes intimating at a kidnapping of his son, and then Richie disappears . . .
Tod and Buz, themselves under suspicion, go on a hunt for the boy in an attempt to solve the mystery.
A Jet-setter named Lola, bored with her rich life, dives overboard the side of her luxury boat and swims for the shore of California's Catalina Island in search of adventure. What she finds is Buz Murdock, working alone on the island, and astonished to see the woman walk towards him out of the water like an incarnation of Aphrodite.
Buz and Lola begin to flirt with each other; but their games soon turn serious when Lola, wandering the beach, manages to get her foot stuck in the rocks in a cove. The high tide is coming in, meaning that the girl could drown in her predicament.
Buz is unable to free the woman without assistance. But Tod has gone to the mainland for supplies, and the resort community is deserted for the off-season. As the waves mount higher and higher the plight of the trapped girl becomes more and more dire as Buz desperately searches for a way to free her or get help.
With Buz laid up in the hospital, Tod is left to work double duty for the duo at the Venice Beach amusement park. One night at a bar, he meets Cris Sinclair, an impulsive and exciting young blonde woman . The next day at work, he is approached by her sister, the reserved and bespectcled Claire, who warns Tod that involvement with Cris may spell disaster for both of them.
Tod enters the world of professional wrestling as he goes to work for a promoter of the "sport". Tod's boss has financed the release of a longtime Hungarian political prisoner named Sandor in order to bring him to the United States to add to his stable of wrestlers. The proud Sandor, accustomed to traditional wrestling, is about to learn what it means to be involved in the Americanized version, where staging and showmanship trump strength and skill.
Tod goes to work at a California zoo where the owner is having nightmares about his first wife being killed by a tiger.
A female doctor hires Tod to search for her missing husband. He finds the missing man who doesn't want to return home to wifey.