In Louisiana, Tod and Buz sign aboard the shrimp boat of captain Charlotte Duval. They find themselves having to deal with their skipper's fierce independence, a jealous suitor and an approaching hurricane.
Now working on an offshore drilling rig in the Louisiana gulf, Tod and Buz become curious about one of their coworkers - an elderly man named Bartlett obviously unsuited for such work. In actuality, Bartlett is really a Holocaust survivor who believes that one of the other workers may be a long-sought Nazi war criminal.
The citizens of rural southwestern Utah fight a daily struggle against the harsh conditions of nature just to maintain the land they live on. A misguided act of kindness brings Tod and Buz into the lives of one such family, the Pages, consisting of three orphaned children. When a well malfunction leaves the Pages facing imminent drought, the boys lend the assistance of their corvette's motor to aid in the repairs. But the remorseless conditions of the inhospitable climate threaten to make their task hopeless.
Tod and Buz arrive in the sleepy coastal town of Grants Pass, Oregon, where they hook on as workers with local hop farmer Gerald Emerson. However, they soon unexpectedly find themselves appointed as babysitters to Emerson's two spoiled and out of control children Curt and Karen. When Curt's irresponsibility costs the lives of one of the workers, our two heroes find themselves the only people in town who will work for the Emersons and must bring the situation to rights.
Making the journey all the way from her native Italy to the Pacific Northwest, Lucia Trapani has come on a holy mission. She has arrived to claim her inheritance to fund the purchase of a Madonna statue for her village church. Unfortunately, her "heritage" is a bogus promise bequeathed her years ago by a well-meaning but imaginative American soldier during World War II - who told Lucia he held the deed to the entire state of Oregon! It's up to Tod and Buz to protect the young woman from disillusionment and find a way for her to fulfill her quest.
Grizzled old prospector Jack McConkle has finally hit upon the strike of a lifetime - discovering a vein of rare Beryllium ore in the desert of the American southwest. However, Tod and Buz's employer, land baron Durant is bent on bullying the old man into relinquishing his claim upon the find. To the rescue come Tod and Buz, determined to protect McConkle's interests. But they are about to find that Durant plays hardball, and their own lives are imperiled by their involvement.
Officials at Carlsbad Caverns National Park are flabbergasted when renown scientist Mark Christopher brings a convoy of families and animals into the caves with every intention of settling down. It seems that Christopher is in possession of information that leads him to believe that Russia is shortly planning to launch a nuclear attack on the US, and he has brought his ragtag group to the caverns in an attempt to survive the holocaust he believes is imminent. Tod and Buz are drawn into the compelling story, and hold their breath along with the rest of the nation as the appointed hour of doom approaches . . .
In El Paso, Texas, Laura Church has just been released from a stay in prison, convicted of an embezzlement she was not guilty of. But her parole officer is none other than local big shot Woody Biggs, the man who framed her in the first place, the man who caused the death of her ex-husband, the man who now has designs on her from which escape seems futile.
Laura's situation seems hopeless. But little does she know that two knight errants have rode into town in the persons of Tod Stiles and Buz Murdock.
Racing fever grips Tod as he lives out a lifelong fantasy to become a race car driver when he is asked to relieve one of the entries in the Grand Prix at Riverside. During preperation for the race, Tod begins to fall for his patron's stepdaughter. But Buz has suspicions that the young woman is just using Tod, attempting to keep him from entering the race for her own purposes.
Tooling around the hot spots of Southern California, Tod and Buz are treated to a performance by jazz trumpet legend Gabe Johnson. However, on the way back from the show, they come to the aid of a crashed motorist , a distraught woman who turns out to be none other than Gabe's wife Jana. Jana claims that her husband is an unstable personality who is trying to kill her.
On the ranch lands of Southern California, Tod and Buz encounter the latest character in their cross-country travels: date rancher Adam Darcey. The invalid Darcey is in mortal combat with the State Highway Department, who wants to build a new road through his property. Darcey keeps vigil on his front porch with a rifle to prevent construction work. Secretly, he is in love with his lovely young ward "Sweet Thing", the apple of the eye of every young man in town.
Tod and Buz motor into Pheonix, Arizona. Tod is thrilled at the prospect of going to work as a prospector for Jack Windus, the man who first taught Tod how to fly. However, when he arrives at the cropdusting outfit, Tod learns that Windus is dead. The business is now run by his wife Dora, who sleepwalks through life, refusing to accept the reality of her husband's death. The chief pilot, Summers, is a brooding depressive convinced that he will bring death and ruin into the life of anyone he is involved with. He attempts to avoid all personal entanglements, including that of his wife Christina, who is hopelessly devoted to him. Tod seeks to convince the reclusive Summers to take him on as an apprentice, while Buz meanwhile begins to fall for Christina . . .
Tod's aspiration to become a cropdusting pilot has led him and Buz into a complex situation involving the interrelationships of the people concerned with the Windus crop dusting company. Tod has succesfully petitioned for the comapny's head pilot Summers to teach him the ropes of the business despite the latter man's reluctance. The financially strapped company is offered a dangerous contract requiring the plane to carry a hazardous load of sulpher. The dramatic events that subsequently unfold make for one of Tod and Buz's most unforgettable experiences in this epic two-parter.
Summoned to his aunt Kitty's deathbed in the slums of Los Angeles, Tod is given a desperate request - to locate her missing daughter Carol, Tod's cousin. Tod's search for the young girl will not only take him through the seediness and violence of life on the wrong side of the tracks - including involving him and Buz in a brutal brawl with a street gang - but will also force him to confront the dark side of his own personality, in one of the grimmest offerings of Route 66's first season.
In San Diego, Tod and Buz become drawn into the lives of preocious nine-year old heiress Linda McKay, and her alcoholic uncle Mike. When Mike's irresponsible behavior threatens to cause him to lose custody of his beloved niece, Tod and Buz step in in an attempt to shape the man up and salvage the situation. But neither them nor Linda is aware of the secret Mike is harboring.
Frank Ivy runs his New Mexico cattle spread like a feudal baron. When his reckless son impregnates a young Indian girl, and then dies in an accident, Ivy kidnaps the young woman and brings her to his estate to raise the child as his own, against the woman's wishes. But among Ivy's ranch hands are employed Tod and Buz, who aid the girl in escaping and in a subsequent attempt to get her to refuge and sanctuary on a reservation. But our two young adventurers soon learn that they will not arrive without first facing one of their most difficult challenges - delivering a baby.
In Youngstown, Ohio, Buz looks forward to a reunion with his boyhood idol, former boxing great Johnny Copa, who is participating in a bout in the city. However, Buz is distraught to find that Copa's career has hit the skids, and that he has been reduced to the status of second-billing punching fodder for up and coming contenders. Buz takes a position in Johnny's corner the night of the bout, determined to help the fighter taste victory once again.
The series concludes a succesful first season with a classic offering set in Cleveland, Ohio - as Tod and Buz become involved in a touching love story featuring two misfits. One a simian construction laborer, the other a mute servant girl.
Broadway sensation Arlene Sims suddenly breaks off her career to return to her hometown of Butte, Montana. Arlene is dying of a rare disease and has come home to spend her final days. But she didn't count on meeting Buz Murdock, who becomes smitten with her. As their relationship grows, Buz contemplates marriage, blissfully unaware that Arelene's time is running out.
To save the life of a wild stallion named "Blue Murder", who has been determined to be too dangerous to be allowed to live, Tod and Buz pledge to personally deliver the horse to rancher Jim Bludge in rural Montana. But when Bludge is found trampled to death, Tod is wracked with guilt and vows to hunt down and kill the animal himself.
In Pittsburgh, Tod and Buz befriend ailing elderly former blues singer Jennie Henderson. They then set out to fulfill Jennie's dying request: to reunite the members of her old combo for one final performance.
On the streets of Boston, Tod and Buz encounter Arnie- a heroin addict in the throes of withdrawal. Tod wants to help the man. However Buz, who has had one too many experiences with junkies in his past, vehemently disagrees - Arnie's case is hopeless, he says, and not worth their time. Tod is puzzled at his usually altruistic close friend's sudden coldness, and wonders at its real cause.
Once again in Cleveland, Tod and Buz become part of the Polish blue collar community. Their boss Jack Kolodziedjczak's greatest pride is his son Janosh, whom he is grooming to be a doctor. But tragedy strikes when Janosh's girlfriend Terry , the daughter of Jack's best friend Mike Palinski is found dead at the bottom of a ravine. With Janosh on the lam, Jack vows to avenge Terry's death, even if it means killing his own beloved son.
Tod and Buz are working in the Adams shipyards in Massachusetts. With the sudden death of the owner, socialite and heiress Prudence Adams arrives for the funeral and to take charge of her father's business. A romance develops between Tod and Prudence, which develops into something serious very quickly. Are there wedding bells in Tod's future?
All his life, Buz has wondered about the mother who abandoned him when he was an infant to live out an orphaned childhood. Now in the small town of Hester, Maryland, Buz has discovered a family - the Colbys - who look like they could be his brothers and sisters. With Tod and a tiny faded photograph, Buz starts on a quest through the streets of Baltimore to find the woman who may be his real mother.
Lillian Aldrich is trying to fit back into society after spending the last eighteen years in a mental hospital. On her first day back at work, she gets into an argument with Buz, who is unaware of her condition. When Lillian flees the office in tears, Tod and Buz learn of the situation. They resolve to help Lillian in her readjustment to normal life and to seek out the daughter who believes her to be dead.
In Pittsburgh, Tod finds himself enamored of lounge singer Perette Dijon. However, Perette is a beautiful princess locked up in a tower - the Mariott Hotel overlooking the city - and the dragon who guards her is her intensely jealous and possessive manager Glenn Ryan. When Tod attempts to court Perette, Ryan knocks him cold with a karate chop. Tod vows revenge and plans for a final showdown with Ryan in his aerie.
Tod and Buz attend a party at a Philadelphia hotel. A misguided prank pulled by a pair of college boys results in Tod drinking a beer that has been spiked with a powerful, experimental hallucinogen. Tod flees the hotel and goes on a one-man rampage through the city as the effects of the drug cause him to experience extreme emotions and sensations: fear, rage, elation, paranoia. Buz and the Philadelphia police force must find Tod before the final phase of the drug takes place - Tod will enter a state of extreme depression in which it is certain he will attempt to take his own life.
In Philadelphia, Tod and Buz pay a visit to Chuck Brennan, a social worker who was instrumental in helping Buz escape a life of juvenile delinquincy as a youth. Brennan continues to work with street gangs, and accepts the challenge of a local gang leader named Packy to a dare game played on the rooftops of the city's apartment buildings. Brennan is killed during the contest, and it falls on Tod, Buz and the gang's reformed former leader Johnny to bring down Packy.
In rural Pennsylvania, Tod and Buz work for the Bracks, a wealthy family led by the domineering widow Agnes. Another widow enters the picture, Agnes' daughter-in-law Julie, who comes overseas from Europe bearing Agnes' grandson. When the family treats her arrival with open coldness and hostility, Tod and Buz are left as the only ones in town who seem willing to offer the young woman hospitality.
Touring historical monuments in Boston, Tod and Buz meet John Westerbrook, an eccentric yet distinguished man who displays a strong patriotism and travels with a small contingent of bodyguards. The boys later learn that Westerbrook is the head of a white supremacist organization. Boston police enlist the aid of our two leads, as Tod works inside the organization and Buz outside. The race is against time, as Westerbrook's organization seems about to be planning something which will result in the deaths of many innoncents.
Tod and Buz pick up work when the traveling rodeo comes to Mesquite, Texas. They come to the rescue of rodeo clown Ollie Crump from hazing at the hands of the outfits cowboys. Ollie is a former rider whose injury has led him to become a clown, and nurses a secret love for alcoholic trick rider Babe Hunter.
Framed for a crime he didn't commit, David Job returns home to his small Texas town following a five-year prison stint. He takes complete control of the town and kidnaps lead citizen Bob Harcourt , the man responsible for his frame-up. David intends to convene a kangaroo court in the local courthouse to pass judgement on Harcourt. Among the enforced participants in the trial are passerbys Tod and Buz.
Tod and Buz are working at a Long Beach veterans hospital. This brings them into the life of Frank Madera, a paraplegic who has been embittered ever since his wife left him, and Lori Barton, the nurse who loves him.
Tod and Buz arrive in Tucson, Arizona, at the same time as Vicki Russell, a free-spirited motorcyclist. Vicki manages to get herself tossed in jail within minutes of coming to town. Buz is fascinated by the young girl's cavalier approach to life and existence and springs for her bail, against Tod's better judgement. However, it is Tod who later falls under Vicki's spell and goes on a joyride with her into the Arizona desert.
In Dallas, Buz is kidnapped by Caine, a religious fanatic who has left a trail of dead bodies across the major cities of the United States. Caine wants the entire city to abstain from sin for twenty-four hours . . . or else Buz will become his latest victim.
Tod and Buz are working as day laborers for a Scottsdale, Arizona, development firm. When the company seeks a new vice president, Terry Prentiss promotes Buz to that executive position as part of a power play to demonstrate to her boss Lee Fisk that a woman can be a corporate executive. Buz, suddenly finding himself in high-rolling executive boardroom meetings, becomes Terry's puppet in this comedy of errors.
When he was an undergraduate at Yale, Tod had a crush on a dancer named Rosemarie Brown. Years later, Rosemarie has fallen on hard times, having just been widowed by an alcoholic husband. Tod and Buz, working for a Hollywood TV station, urge Rosemarie to audition for a dance troupe for one of their shows as a means to get her back on her feet.
Tod is hired for a special assignment - to be the special assistant to speed boat motor designer Sandy Mason. The demands of this driven man who is on the verge of a revolutionary breakthrough in engine design keep Tod working overtime. But when Mason's prodigal daughter arrives on the scene, Tod finds himself drawn just as intensely into the man's personal life as well as his professional.
Buz is knocked out during a construction work accident, and when he regains consciousness he finds that he is unable to see! A doctor tells him his loss of vision may be temporary, or it may be permanent. Buz first contemplates taking his own life, but then agrees to enroll in a Texas institute for the blind so that he can retrain himself to live in society. Buz is assigned a young blind woman as his teacher, and as he gradually begins to cope with both his blindness and becoming part of the world again he begins to fall in love with the young woman. This episode marks one of George Maharis' most memorable performances of the series.
After stopping to help a young woman with car trouble, Tod and Buz find themselves part of a kidnapping. They soon learn that the woman is the daughter of famed embezzler and international fugitive Charles Clayton. Clayton has risked recapture to come back to the United States to visit his daughter.
While working as deckhands on a Cleveland river tour ferry, Tod and Buz come to the rescue when a young boy goes off the boat into the water. The boy, Richie McIntyre turns out to be the son of local business tycoon Willard McIntyre, and claims that he did not fall overboard, but was pushed. Then the elder Mcintyre begins receiving threatening notes intimating at a kidnapping of his son, and then Richie disappears . . .
Tod and Buz, themselves under suspicion, go on a hunt for the boy in an attempt to solve the mystery.
A Jet-setter named Lola, bored with her rich life, dives overboard the side of her luxury boat and swims for the shore of California's Catalina Island in search of adventure. What she finds is Buz Murdock, working alone on the island, and astonished to see the woman walk towards him out of the water like an incarnation of Aphrodite.
Buz and Lola begin to flirt with each other; but their games soon turn serious when Lola, wandering the beach, manages to get her foot stuck in the rocks in a cove. The high tide is coming in, meaning that the girl could drown in her predicament.
Buz is unable to free the woman without assistance. But Tod has gone to the mainland for supplies, and the resort community is deserted for the off-season. As the waves mount higher and higher the plight of the trapped girl becomes more and more dire as Buz desperately searches for a way to free her or get help.
With Buz laid up in the hospital, Tod is left to work double duty for the duo at the Venice Beach amusement park. One night at a bar, he meets Cris Sinclair, an impulsive and exciting young blonde woman . The next day at work, he is approached by her sister, the reserved and bespectcled Claire, who warns Tod that involvement with Cris may spell disaster for both of them.
Tod enters the world of professional wrestling as he goes to work for a promoter of the "sport". Tod's boss has financed the release of a longtime Hungarian political prisoner named Sandor in order to bring him to the United States to add to his stable of wrestlers. The proud Sandor, accustomed to traditional wrestling, is about to learn what it means to be involved in the Americanized version, where staging and showmanship trump strength and skill.
Tod goes to work at a California zoo and amusement park, Jungle Land in Thousand Oaks, where the owner is having nightmares about his first wife being killed by a tiger. The owner's second wife helps him confront his lingering issues surrounding the incident.
A female doctor hires Tod to search for her missing husband. He finds the missing man who doesn't want to return home to wifey.
Working on a fishing boat in Astoria, Oregon at the mouth of the Columbia River to the Pacific Ocean, Tod gets into a violent and ongoing feud with an established and possessive fisherman over the beautiful daughter of Tod's boat's owner. Buz has joined Tod on this trip and has had problems with this same fisherman.
In rural Missouri, Tod and Buz pick up a hitchhiker on their way to go fishing. The man is reputed to be a big time jinx.
Tod and Buz are in Chicago, Tod as a taxi driver, who picks up a former prohibition gangster, who thinks someone from his past is out to kill him.
Working as a motel lifeguard in Chicago, Buz attempts to play matchmaker for his supervisor and a motel telephone operator.
Working in an Oregon paper mill, Tod and Buz rent a room from a dysfunctional family.
Tod and Buz are waiting at a Cleveland, Ohio railroad station for a bridesmaid. Tod is kidnapped while helping a convicted murderer, who is on a layover during a transfer to a distant prison, meet up with his brother.
A girl is suffering from the same disease that killed her mother and an operation might not save her.
Tod and Buz go to work as shark hunters for a doctor doing research on the creature. But the doc's wife wants him to return to his regular practice.
Tod and Buz decide to leave Cleveland because of the predictions of a nightclub mentalist about them which keep coming true.
Tod searches for a female bail jumper who conned him into letting her escape.
Tod reunites with old love interest Vicky Russell in Memphis, Tn and discovers that she is getting married to someone else.
Tod befriends a Hollywood songwriter in a small Tennessee town.
Tod and Buz pick up a young German seaman who has jumped ship in order to kill the man reputed to be his father.
Working in the Los Angeles oilfields, Tod thinks he's finally met the girl of his dreams but the dream soon turns into a nightmare.
A woman just released from prison after 27 years for killing her father is told by her uncle that Tod is her son.
Tod becomes involved with a woman who believes that her stepfather is trying to kill her wealthy mother.
Tod meets a man named Lincoln Case, a Green Beret who has returned home from Vietnam, and becomes Tod's new traveling companion.
Tod and Linc are working at Florida's Wikkee Watchee theme park, where Tod meets a young lady who claims to be a real mermaid.
Tod and Linc get involved in helping two Cuban refugee brothers get their niece out of Cuba.
Tod and Linc visit Linc's former commanding officer from Vietnam who, because of a combat injury to the head, has the mentality of an eight-year-old.
Two rich gals who have always been competitors make full use of Tod and Linc by entering them in a power boat race.
While walking to a gas station to get fuel for Tod's Corvette, Linc is kidnapped by two men on their way to a wedding.
Linc is falsely accused of injuring a dog in the neighborhood where he is working.
Tod and Linc come to the aid of a transient hobo who's accused of bringing a sleeping virus to a small Missouri town.
While working as a camp counselor, Linc becomes involved with an older woman who's being stalked by her deranged former husband. Meanwhile, Tod tries to fend off the affections of a much younger female camper.
Tod and Linc become involved in a long lost son's grudge against his father.
In Minnesota, Tod and Linc become involved with an eccentric farmer who refuses to try new methods and his son who wants to sell the farm to make room for a motel to be built on the property.
In Colorado, Linc's old Vietnam buddy and a visiting woman become trapped in a mine cave-in. As rescue workers hurry to save them their past miserable lives emerge.
In the backroads of Vermont, Linc and Tod try to help out an old farmer who's made it this far without modern conveniences but finds that time might be catching up.
An aging bank robber, who's wanted by the law, selects a young woman to turn him into the law for a substantial reward but the damsel has problems of her own and may not be able to oblige.
While visiting Toronto in the Dominion of Canada, Tod and Linc try to help a stranded all girl jazz band get back to St. Louis.
Tired of their parent's quarreling, a two children take their baby brother and set up their own household.
To fulfill the last wish of a dying plane crash victim, Tod and Linc head to Savannah to search for the man's child who was born 25 years prior in order to give her an inheritance of $38,000.
Tod and Linc find work with a sign company in Savannah. When a recently discharged Army vet damages a sign they are delivering they try to discover his reasons for doing so.
Linc crosses paths with a former soldier from his unit in Vietnam who was responsible for the men in Linc's unit getting killed.
Working on a construction project in Minneapolis, Linc becomes involved with the neurotic sister of his boss.
On the east coast of Florida, Tod and Linc make the acquaintance of an alcoholic boxer and his galpal. Tod is skeptical but Linc wants to lend them a hand.
Tod runs into an old college chum from Yale in St. Augustine, FL and gets involved in the chum's scheme to find himself a wife.
A teenager holds Tod and Linc hostage after accidentally killing a policeman.
Tod is kidnapped by a political assassin who is his exact double.
Working in Tampa, Todd and Linc become involved with a family of eccentrics and the reading of a will.
In the series finale, Linc and Tod reach the end of the line in Tampa. Tod decides to get married and settle down while Linc heads on down the road to whatever destiny awaits.