Coulson and his team are now wanted fugitives with limited resources -- but that's not stopping them from keeping the world safe from powerful and unseen threats everywhere. However, with new members they hardly know, will S.H.I.E.L.D. ever be trusted again?
Hunted and running out of solutions, Coulson puts his team right in the line of fire in the hopes of saving them all. But with General Talbot, HYDRA and Creel all on the attack, can they possibly survive? Meanwhile, a mysterious Doctor harbors some dangerous secrets that could destroy one of our core team members.