Hosting the 20th season premiere is comedian Steve Martin, his 13th time hosting. Musical Guest is Eric Clapton.

Sketches: "Clinton Auditions," "The Ron Wood Show," "Baseball Cruise," "Steve Martin's All-Natural Penis Beauty Creme," "Bad Ad Campaign," "Court TV: O.J. Simpson Trial," "Total Bastard Airlines," "The Better Baby," "Bathroom Monkey," "Deep Thoughts by Jack Handey," and "Leland-Meyers Home Headache Test."

Eric Clapton performs "I'm Tore Down" and "Five Long Years."