Actress Amy Adams hosts; Vampire Weekend performs "A-Punk" and "M79."

Sketches include "An Unfair and Deceptive Message from Hillary Clinton," "Mirror Image," "Couples Therapy," "Fierce: The Hot Mess Make-Over Show," "Weekend Update" with guests Sen. Tim Calhoun and comedian Jean K. Jean, "Penelope at Traffic School," "Dr. Uncle Jimmy's Smokehouse and Outpatient Surgical Facility," "Roger Clemens Presents," "The Tookie Styles Show," and "Celebrations."