DI Lestrade: Well, we got him. And there's one person that we have to thank for giving us the decisive leads. With all his customary diplomacy and tact.
John: Sarcasm.
Sherlock: Yes.

John: Remember...
Sherlock: Yes.
John: Remember...
Sherlock: Yes.
John: Remember what they told you. Don't try to be clever...
Sherlock: No.
John: And please, just keep it simple and brief.
Sherlock: Confidence, star witness, come across as intelligent.
John: Intelligent, yes. Let's give "smart ass" a wide berth.
Sherlock: I'll just be myself.
John: Are you listening to me?!?

Prosecuting Barrister: How would you describe this man, his character?
Sherlock: First mistake. James Moriarty isn't a man at all. He's a spider. Spider at the center of a web. Criminal web with a thousand threads and he knows precisely how each and every single one of them dances.

Sherlock: How long have I known him? Not really your best line of inquiry. We met twice, five minutes in total, I pulled a gun, he tried to blow me up. I felt we had a special something.

John: Don't do that.
Sherlock: Do what?
John: The look.
Sherlock: Look?
John: You're doing the look again.
Sherlock: I can't see it, can I? (John points to a mirror) It's my face.
John: Yes, and it's doing a thing. You're doing a, "We both know what's really going on here" face.
Sherlock: But we do.
John: No. I don't, which is why I find the face so annoying.

Jim Moriarty: It's going to start very soon, Sherlock. The fall. But don't be scared. Falling's just like flying except there's a more permanent destination.

Sherlock: Linseed oil.
Anderson: Not much use. Doesn't lead us to the kidnapper.
Sherlock: Brilliant, Anderson.
Anderson: Really?
Sherlock: Yes. Brilliant impression of an idiot.

Sherlock: I need your help. It's one of your boyfriends, we're trying to track him down. He's a bit naughty.
John: It's Moriarty.
Sherlock: Of course it's Moriarty.
Molly Hooper: Um, Jim wasn't even my boyfriend. We went out three times. I ended it...
Sherlock: Yes, and then he stole the Crown Jewels, broke into the Bank of England, and organized a prison break at Pentonville. For the sake of law and order, I suggest you avoid all future attempts at a relationship, Molly.

DI Lestrade: Now remember, she's in shock and she's seven years old, so anything you can do to...
Sherlock: Not be myself.
DI Lestrade: Yeah. That'd be helpful.

John: No, I know you're for real.
Sherlock: One hundred percent?
John: Nobody could fake being such an annoying dick all the time.

Sherlock: Molly, I think I'm going to die.
Molly Hooper: What do you need?
Sherlock: If I wasn't everything that you think I am, everything that I think I am, would you still want to help me?
Molly Hooper: What do you need?
Sherlock: You.

John: She's dying, Sherlock. Let's go.
Sherlock: You go, I'm busy.
John: Busy?
Sherlock: Thinking, I need to think.
John: You need to... doesn't she mean anything to you? You once half-killed a man because he laid a finger on her.
Sherlock: She's my landlady.
John: She's dying... you machine. Sod this. Sod this, you stay here if you want, on your own.
Sherlock: Alone is what I have. Alone protects me.
John: Nope. Friends protect people.

(to Sherlock)
Jim Moriarty: All my life I've been searching for distractions, and you were the best distraction, and now I don't even have you. Because I've beaten you. And you know what? In the end it was easy. It was easy. Now I got to go back to playing with the ordinary people. And it turns out you're ordinary, just like all of them. Oh well.

Jim Moriarty: You think you can make me stop the order? You think you can make me do that?
Sherlock: Yes. So do you
Jim Moriarty: Sherlock, your big brother and all the king's horses couldn't make me do a thing I didn't want to.
Sherlock: Yes, but I'm not my brother, remember? I am you, prepared to do anything. Prepared to burn. Prepared to do what ordinary people won't do. You want me to shake hands with you in Hell, I shall not disappoint you.
Jim Moriarty: No. You talk big. No. You're ordinary. You're ordinary, you're on the side of the angels.
Sherlock: Oh, I may be on the side of the angels. But don't think for one second that I am one of them.

John: Hmm, you--you told me once that you weren't a hero. Umm, there were times I didn't even think you were a human, but let me tell you this. You were the best man, the most human human being that I've ever known, and no one will ever convince me that you told me a lie. And so there. I was so alone, and I owe you so much. Oh, please, there's one more thing, one more thing. One more miracle, Sherlock, for me. Don't be dead. Would you do that just for me, just stop it? Stop this.