| Name (Sort) | Character (Sort) | |
| •Peter Krause | played | Nate Fisher (63Eps.) |
| •Michael C. Hall | played | David Fisher (63Eps.) |
| •Frances Conroy | played | Ruth Fisher (63Eps.) |
| •Lauren Ambrose | played | Claire Fisher (63Eps.) |
| •Rachel Griffiths | played | Brenda Chenowith (39Eps.) |
| •Freddy Rodriguez | played | Federico Diaz |
| •Richard Jenkins | played | Nathaniel Fisher |
| •Mathew St. Patrick | played | Keith Charles |
| •James Cromwell | played | George Sibley (S04-S05) |
| •Lili Taylor (2) | played | Lisa Kimmel Fisher (S01-S02) |
| •Justina Machado | played | Vanessa Diaz (S03-S05) |
| •Jeremy Sisto | played | Billy Chenowith (episodes 5 -13; recurring otherwise) |