While enjoying a long-deserved vacation, Scott and Stonebridge are recalled to duty after a fellow Section 20 member dies while pursuing the elusive terrorist Al-Zuhari in Beirut. A new lead sends them into the remote jungles of Colombia, in pursuit of a known associate of Al-Zuhari’s.
Out of options and being hunted by a cartel, the Section 20 team desperately attempts an assault in downtown Bogota, hoping to obtain intel on one of Al-Zuhari’s key operatives. Elsewhere, Dalton searches for the source that exposed her team in Beirut and finds a surprising ally and also some info about Al-Zuhari’s plan.
While uncertain where other people's loyalties lie, the team must work with an asset in Beirut in an effort to get a lead on James Leatherby, a dangerous and unpredictable operative with possible ties to Al-Zuhari.
Section 20 attempts the risky rescue of the daughter of a potential new ally. Now teetering close to the edge, but determined to find the truth, Dalton goes AWOL with a recently captured detainee.
While trying to recover from a shocking turn of events, Section 20 faces a different threat when a new enemy joining forces with an old one. Locke attempts to draw Kamali in closer to the team. Scott looks for an old friend, while Stonebridge gets closer to a new one.
Locke has trouble deciding whether to devote their resources to the mission or to saving one of their own people. Stonebridge's growing health problem continues to affect him in the field. Kamali explains why yet another threat is emerging and Al-Zuhari's terrorist network strikes closer to home.
Section 20 tracks the stolen property to Russia, where Scott and Stonebridge come up with an unorthodox plan to enter the prison. Kamali is worried that his cover identity may be in danger of being exposed as fake. While in the prison they discover new mysteries about a piece of Al-Zuhari's plan, but Stonebridge's health continues to deteriorate.
While the rest of Section 20 races to locate Stonebridge, whose condition is worsening by the minute, Scott looks for a way to escape the prison. Locke has his suspicions about Kamali's actions; and Ulyanov continues to hunt for Scott and Stonebridge, to enact revenge for his dead son.
Scott and Stonebridge attempt to protect Kamali's daughter Ester from being abducted. Martinez and Richmond's questioning of a suspect captured during the raid, results in a possible lead to an associate of Al-Zuhari, and may target a potential infiltrator.
After finding out that Kamali is still alive, Locke makes a deal with Arkady in an effort to secure the antidote to the virus before the entire city becomes infected.