Ra's Al Ghul finds a way to prevent his impending death, which presents itself as Superman's DNA. It's up to Batman to stop him before it's too late.
In another effort to take over Earth, Darkseid brainwashes Superman and tuns him loose against humanity.
Superman is determined to make Darkseid pay for what he did to him, but realizes that recovering humanity's trust in him will be more difficult than anything he has ever done.
Superman must fight Brainiac and Lex Luthor, two of his greatest enemies, as he tries to confront his love for Lois Lane.