Sam conducts a desperate search for Dean, unaware that he's now a demon and allied with Crowley. Meanwhile, Hannah appeals to Castiel to help her track down two rogue angels.
Dean continues to defy Crowley, going his own way, and the King of Hell turns to an unexpected ally for help. Meanwhile, Cole tortures Sam for Dean's location, while Castiel grows increasingly worse with the loss of his grace, forcing Hannah turns to an imprisoned Metatron for help.
Sam tries to cure Dean using injections of sanctified blood, but Dean insists that he doesn't want to be cured... and the attempt may kill him. Meanwhile, Crowley discovers that his recent sojourn with Dean has undermined his authority in Hell, and Castiel gets help from an unexpected ally.
While recovering from their recent trials, Sam and Dean decide to go on an "easy" hunt for a werewolf. However, they discover that it's Kate, the werewolf that they let go a year earlier.
While on a case, Sam and Dean discover that a all-girl's school is producing a musical based on their lives... or at least, based on their lives as told by the prophet Chuck in the Supernatural books.
Sam and Dean discover that someone has requested Bobby's presence at the reading of a will. When the brothers arrive, they discover a family of mourners that aren't so mournful... and a killer among them.
While Hannah confronts a blast from her host body's past, Sam and Dean track down a witch who is trying to form a new coven... and has an unexpected connection to Crowley.
While attending a sheriff's retreat, Jody stumbles across a case involving murder victims who are brutally murdered and then eaten. She calls in the Winchesters and they try to investigate the case while avoiding Donna Hanscum, a sheriff who they've run into before.
Castiel decides to make amends for taking the body of Jimmy Novak by getting Jimmy's daughter Claire out of a group home. Meanwhile, Dean is plagued by visions of bloodshed due to the Mark. And in Hell, Crowley tries to deal with his mother Rowena.