Sam and Dean head to Colorado to check out the coordinates that their father left them in his journal. When they arrive, they pose as park rangers to investigate the disappearance of three campers and soon discover that they're up against a Wendigo, a mythical creature from Native American folklore.
Dean comes across an article about a mysterious drowning. Sam and Dean soon find that several people have drowned in the same lake, but bodies were never found, suggesting that a spirit is haunting the lake.
APM -- At Rest, Spit Habit
-- Merry Go Round, Low Five -- Noise, Boston
-- Peace of Mind, APM -- Royal Bethlehem, Paul Richards
-- U Do 2 Me
A gas & power worker is killed when insects burrow themselves into his brain and consume it. Sam and Dean research the history of the new housing development and find that it has been constructed on former Indian land cursed against the white man. Now, it's up to the brothers to get the people out before they are killed by swarms of bees, locusts, spiders, and beetles.
The Scorpions -- No One Like You, Def Leppard
-- Rock of Ages
Sam and Dean travel to an abandoned sanitarium where they find that the patients once revolted against cruel and unusual punishments given to them by the head doctor. The brothers search the area for lost college students, but the spirits make them go insane, and end up turning Sam against Dean.
Songs: Bachman Turner Overdrive -- Hey You
Sam and Dean part ways when Sam insists on ignoring John's orders and tracking down Jessica's killer. Dean travels to a town that's hiding a dark secret about a scarecrow, and their perpetual prosperity, while Sam meets up with an attractive hitchhiker.
During a fight with a hobgoblin, Dean is electrocuted, causing deadly damage to his heart. Sam tries to find a way to save Dean, and comes across a preacher who claims he can cure the incurable. But the brothers soon discover that the preacher's miracles are happening due to help from the Grim Reaper, who trades one life for another, "less worthy" life.
Sam has a premonition about a man's death that is staged to look like a suicide. Once Sam convinces Dean to investigate the case, they are puzzled when they can't find proof that something supernatural was behind the death. However, they soon realize that the dead man's son, Max, has telekinesis and is using it to kill off his abusive family members.
Sam and Dean head to Minnesota where a young boy witnesses a man vanish into thin air. Shortly after arriving, Sam is targeted by the same abductor, and Dean is left to search for his brother. However, the brothers discover that their kidnappers are humans, using the captives as human prey for their sadistic "hunting expeditions."
Dean and Sam track down the ghost of Mordechai Murdoch, who haunts an old Texas farmhouse. However, the brothers discover that Mordechai is a tulpa, created by thousands of people believing in it after the fake legend of him was posted on a popular website. Now, Sam and Dean must stop the spirit from killing any more people who enter the house.
When Sam and Dean find articles about a town where children are inexplicably falling into comas, the brothers discover that a Shtriga, a creature that attacks children, is behind the mysterious comas. During the battle, Dean remembers a past battle with the creature that almost resulted in Sam's death.
-- Rock Bottom
When a young couple mysteriously die after buying a portrait of a 1910 family, Sam and Dean travel to the scene to investigate the painting. The brothers find that each owner of the painting has ended up dead due to a dangerous spirit bound to the portrait. Can they stop it before it kills again?
Steve Carlson Band -- Night Time, Extreme
-- Romantic Pieces, No.1, Grand Funk Railroad
-- Bad Time, Black Toast Music -- One More Once
To save their father, Sam and Dean enlist the help of a family friend, Bobby Singer. When Meg shows up at Bobby's home, the brothers are able to exorcise the demon from her body and get her to tell them where their father is being held. The brothers race off to rescue their father, resulting in a final showdown between the Winchesters and the demon they have spent their lives looking for.