Crowley: Werewolves turning on the full moon. How '09.

Sam: Look. This is a crap situation. I get it. But Dean, I am still me. Same melon, same memories. I still like the same music. I still think about Susie Eiser.
Dean: Biology class Susie Eiser?
Sam: Can you blame me?

Detective: Feds?
Sam: Yeah.
Detective: What are the Feds doing here?
Sam: Oh, we're specialists. They call us in to answer the questions of mouth-breathing dick-monkeys.

Sam: Boy, Cal doesn't know when to quit.
Dean: Three scuzzy bars, one scuzzy strip joint, a chili dog joint, seven or eight nightcaps, and now Scotches in the library. I'm getting cirrhosis just watching this.

Sam: Roll over, Lucky. Speak.
Lucky: Go to Hell.
Sam: Already been. Didn't agree with me.

Lucky: Me, I was living on the streets. They found me, they told me one small bite, I'd be strong, I'd be fast.
Dean: Sniffing people's butts. Yeah, that's a real step up.
Lucky: Well, it was for me.

Sam: Look, I don't know if how I am is better or worse. It's different. You get the job done, and nothing really hurts. It's not the worst thing. But... I've been thinking. I was that other Sam for a long time. And it was... it was kinda harder. But there are also things about it I remember that I... Let's just say I think I should go back to being him.
Dean: That's very interesting. It's a step.
Sam: So?
Dean: We do what we got to do. And we get my brother back.

Title:

All Dogs Go to Heaven is a 1989 animated movie about a dog that dies and seeks revenge, even though it will put him into Hell.

Dean: Agents Holt and Wilson.

Holt and Wilson are police officers in the 1981 movie Wolfen, which features intelligent wolves stalking man in the cities.

Dean: Let me get dressed, Robocop.

Robocop was a 1987 movie featuring a police officer turned into an emotionless cyborg programmed to enforce the law.

Sam: Masterful deduction, Sherlock.

Sherlock Holmes is the famous literary consulting detective created by Sir Arthur Conan Doyle.

Sam: Dogs and cats living together--mass hysteria.

Bill Murray uses the same line to describe the unleashing of ghosts in New York City in Ghost Busters (1984).

Dean: Where's this little Scooby Gang of yours?

Scooby Doo is the popular animated Great Dane who starred in the Hanna-Barbera cartoons involving Scooby and the Scooby Gang. The other members are Fred, Velma, and Daphne.

Dean: Thanks, Dexter, that's reassuring.

Dexter Morgan is a psychopathic serial killer in a series of novels by Jeff Lindsay, and a critically-acclaimed TV series on Showtime.