Alpha Shapeshifter: It's Purgatory. All I know is that I go there when I die. It's not like I can draw you a map.
Crowley: I happen to know you can.
Alpha Shapeshifter: You're wrong.
Crowley: My sources are unimpeachable. You're the father of your entire species. You're really not pulling off this dumb blonde act. I hope you appreciate how much effort I've gone to... to find something that can actually hurt you. Yeah, my tinkering has got several lesser shifters their lives. Iridium. Rarer than hell. Would have been cheaper to drop a castle on you, but I think we all agree, worth it. So... you start talking, or I start chopping off all the bits that stick out.

Dean: Where's Crowley?
Sarcastic Demon: Banging a hooker in a sweet spot called "none of your business."
Dean: Whoa. Look at that, Sam. Demon trying to be funny.
Sam: Oh, is that what just happened?
Sarcastic Demon: Goodnight, girls.
Dean: Wait, wait, hold up. Are we ever going to see Crowley again, or he is just going to keep sending his demon extras to pick up his laundry?
Sarcastic Demon: I'm sorry. I know you're speaking, I see your lips moving, but I can't understand what you're saying because I don't understand Little Bitch!

Dean: What now?
Sam: I think I know who you can ask.
Dean: Evil bitch.
Meg: Keep sweet-talking me, this could go a whole new direction.

Sam: Cas, we found something. It's this--this gold box. Apparently Nazis were after it back in the day. Someone tried to open it and their face melted off. Think it's--ready for this? The Ark of the Covenant. Yeah. So...
Castiel: I'm here, Sam. Where's the box?
Sam: I can't believe you fell for that. That was the plot of Raiders, idiot.

Dean: Mom.
Samuel Campbell: He's going to give her back to me.
Dean: Crowley's going to bring Mom back from the dead?
Samuel Campbell: You tell me you don't want her back. You know the one difference between us? You know how to live without her.

Castiel: It's very complex.
Dean: Umm-hmm.
Castiel: If the pizza man truly loves this babysitter... why does he keep slapping her rear? Perhaps she's done something wrong.
Dean: You're watching porn? Why?
Castiel: It was there.
Dean: You don't watch porn in a room full of dudes. And you don't... talk about it. Just turn it off! (Castiel glances down) Now he's got a boner.

Samuel Campbell: This what you boys do, sit around watching porno with angels?
Castiel: I'm not supposed to talk about it.

Meg: Remember me? I sure remember you, Clarence.
Castiel: Why are we working with these... abominations?
Meg: Keep talking dirty makes my meat suit all dewy.

(after Castiel kisses her)
Meg: What was that?
Castiel: I learned that from the pizza man.
Meg: Well, A+ for you. I feel so... clean.

Dean: Sam?
Sam: Yeah?
Dean: I'm standing in pee.
Sam: Consider yourself lucky.
Dean: Yikes. That sucks.

Samuel: No, really, tell me. Exactly what are you supposed to be to me?
Dean: I'll tell you who I am. I'm the guy you never want to see again. Because I'll make it out of here, trust me. The next time you see me, I'll be there to kill you.
Samuel: Don't think there's going to be a next time.
Dean: Whatever gets you through the night.

Title:

Caged Heat is a 1974 women-in-prison exploitation movie.

Sam: Cas, we found something. It's this--this gold box. Apparently Nazis were after it back in the day. Someone tried to open it and their face melted off. Think it's--ready for this? The Ark of the Covenant.

As Sam notes, he is stealing from the plot of Raiders of the Lost Ark (1981), which features globe-trotting adventurer Indiana Jones fighting Nazis who are attempting to find and use the Ark of the Covenant.

Meg: I sure remember you , Clarence.

Clarence Odbody is the guardian angel in the 1946 movie It's a Wonderful Life.

Dean: I mean, the guy's a freakin' replicant.

Blade Runner (1994) featured replicants, biorobotic simulations created to mimic humans. They purportedly lack emotion and empathy.

Dean: Shawshank's a great flick, but let's skip the shower scene, okay.

The Shawshank Redemption is a 1994 movie based on a Stephen King novella, set in a men's prison where the main character is raped.