Eve: God doesn't care about you.
Rick: Sure He does.
Eve: Your Father made you and then abandoned you. So you pray. You see signs where there's nothing. But truth is, your Apocalypse came and went, and you didn't even notice. A mother would never abandon her children like He did. You'll see.
Rufus Turner: So.
Bobby Singer: So what?
Rufus Turner: So we partnering on this or not? Come on, it's not rocket surgery. We're here, lets do this. Just like old times.
Bobby Singer: As long as I get to drive.
Rufus Turner: Hell, no.
Sam: It really is good to see you, Rufus.
Rufus Turner: I can believe it. It must get old dealing with this miserable cuss here all by yourselves.
Sam: Is it that obvious?
Bobby Singer: Why don't you three get a room?
Bobby Singer: So... you're Samuel.
Samuel Campbell: You must be the guy pretending to be their father.
Bobby Singer: Somebody ought to.
Dean: I'm not in the mood. I just had a 12" herpes crawl out of my ear.
Dean: You heard me.
Sam: You saying he wasn't a monster when I ganked him?
Rufus Turner: One way to find out. Bobby, you got a cranial saw in the car?
Bobby Singer: Of course.
Rufus Turner: And I want you and you... okay, I want you and you to watch him and him... all right, if anything crawls out of anybody, step on it.
Sam: What he did to us... but...
Dean: There's a but?
Sam: I can't help but think , what would Mom say?
Dean: You know what I think Mom would say? She'd say, "Just because you're blood doesn't make you family. You got to earn that."
Rufus Turner: This can't be the afterlife because the three of you are here.
Dean: Hey there, you little herpes.
Sam: Why do you keep talking about herpes?
Dean: What? I don't. Shut up. Shut up!
Dean: Who is she, this Eve bitch?
Possessed Bobby: The Mother of All of us. And the end of all of you. By the time she's done, there'll be more creatures than humans. You'll live in pens. We'll serve up your young and call it veal.
Bobby Singer: It was Omaha. It was my fault. And he never let it go.
Dean: Well, he should have.
Bobby Singer: You don't know what I did, Dean.
Dean: It doesn't matter.
Bobby Singer: What do you mean, it doesn't...?
Dean: I mean, at the end of the day, you two are family. Life is short, and ours are shorter than most. We gonna spend it wringing our hands? Something's going to get us, eventually. And when my guts get ripped out, just so you two know, we're good. Blanket apology for all the crap that anybody's done, all the way around.
Sam: Some of us pulled a lot of crap, Dean.
Dean: Well, clean slate.
Title: And Then There Were None
And Then There Was None is a mystery novella written by Agatha Christie in 1939. In it, ten individuals are invited to an isolated island, stranded, and realize that one of them is a murderer... and eliminating the others, one at a time.
Rufus Turner: Same as you, tracking 31 flavors of crazy.
Baskin-Robbins Ice Cream carries 31 flavors at any given time in their stores.
Dean: It’s like a Khan worm on steroids.
The second Star Trek movie, The Wrath of Khan, had the villain place Ceti eels in the ears of his victims. The creatures burrowed into the brain, making the victim suggestible.
Samuel Campbell: Just because you're Dr. Jekyll at the moment doesn't mean you get all high and mighty.
Dr. Jekyll is the mild-manner protagonist to his beastial alter-ego, Mr. Hyde, in Robert Louis Stevenson's 1886 novel.
Rufus Turner: All right, lets play Operation.
Operation is a board game where you attempt to remove plastic body parts from a board representing a human body, and contacting the metal edges with your metal tweezers sets off a buzzer, meaning you "lose."
No way out now, Sluggo.
Mr. Sluggo is the antagonist in the Mr. Bill series of skits on Saturday Night Live