Sam: I can't believe I'm about to say this, but I hope you're watching cartoon smut. Because reading Dick Roman crap over and over again is just... self-punishment.
Dean: It's called anime, and it's an artform.

Sam: Well, there's a semi-functional bathroom and one un-rancid bedroom.
Dean: Describe "semi-functional," and do not use the words "hole in the floor."

Sam: You going to look at more anime, or are you strictly into Dick now?

Elliot Ness: Ezra Moore, Dean Winchester.
Dean: Hey.
Ezra Moore: Who's he, some farmer clown?
Elliot Ness: He's, uh, from the future.
Dean: Yeah. Gas costs four bucks, you get cheese out of a spray can. The President is a black man. I could go on.
Ezra Moore: Paint me impressed.

Dean: Awesome.
Ezra Moore: "Awesome"? Is he some religious kook?
Elliot Ness: No, he just likes saying that.

Elliot Ness: You said you fellas found his house. Well, let's go see if it's been built yet. And then let's kill that bastard. Because that...
Dean: Is the Chicago Way.
Ezra Moore: "Chicago Way"?
Elliot Ness: Who--who talks like that?
Dean: Sean Connery.
Ezra Moore: Come on.
Dean: Never watch that movie again.

Elliot Ness: Look. You seem like a swell guy, Lester. I want to help you out, I do, but my partner just got back from the War. He spent the last two years kicking in Nazi skulls. If he doesn't kick in a skull every couple of days, he's really touch.
Dean: Lester. Is that a German name?!?

Elliot Ness: Yeah, hunting sets me free. Isn't that why you hunt?
Dean: I used to do it because that's what my family did. But they just seemed to keep dying. tell you the truth, I don't know why I'm doing much of anything anymore.
Elliot Ness: Boo hoo, cry me a river, you nancy. Tell me, are all hunters as soft as you in the future? Everybody loses everybody and then one day, boom, your number is up. But at least you're making a difference. So enjoy it while it lasts kid, because hunting is the only clarity you're going to find in this life. That makes you luckier than most.

Dean: That's it?
Ezra Moore: That is a thousand-year-old olive carved by vestal virgins and dipped in the blood of... you don't want to know. Pulling this together wasn't easy. You and Ness both owe me, smoothie.
Dean: You can have whatever you want. Soon as we gank this thing.
Ezra Moore: Yeah, yeah, take your twig, wise guy.
Dean: Well how's it work?
Ezra Moore: You stick this end in his heart. Miss, he has you for supper.

Cronus: You want to know your future? I know your future. It's covered in thick, black ooze. It's everywhere. They're everywhere. Enjoy oblivion.

The conversation in the two supposedly identical scenes doesn't match. The first time the brothers spot the killer, Sam says, "Wait wait wait. What's the plan here exactly?" The second time when they repeat the scene, Sam says, "Whoa, whoa. What's the plan here exactly?"

Dean: I’m 12 Monkeys no matter what I say, so here goes.

In the 1995 science fiction movie 12 Monkeys, Bruce Willis' character travels into the past of 1995, ends up in 1990, and everyone assumes that he's insane when he talks about time travel.

Dean: He’s using the Biff strategy.

In Back to the Future II (1989), Biff Tannen steals a sports almanac and travels into the past to give his younger self the means to bet on sporting events and make himself wealthy.

Dean: Back to the Future III.

In the Back to the Future movies, people leave a message in the past so that it will be delivered in the future to the person they want and give a warning.

Dean: Yes, sir, I am, uh, Special Agent Costner.

Kevin Costner played Eliot Ness in the 1987 movie The Untouchables.