Kate: Look, I mean, there's got to be an explanation for this.
Brian Wilcox: Really?
Kate: It... was self-defense.
Brian Wilcox: Eating a heart is self-defense?
Sam: Dude, two burgers?
Dean: Hey, I didn't eat at Big P's for at least a year, okay? Clear eyes and clogged arteries--can't lose.
(about Sam and Dean)
Kate: First things first, those guys... those guys aren't FBI, all right? I'm pretty sure that FBI agents don't say "awesome" that much. You know? And--and they definitely don't hunt and kill college kids.
Mike Wheeler: Did--did they say anything else?
Brian Wilcox: Dude, they just sat and talked about how they've been apart for a year. You were probably right about that whole office-romance thing.
Dean: Hey, Sam?
Dean: Do I really say "awesome" a lot?
Sam: No. No, no, no.
Kate: But of the two, I prefer Last Year at Marienbad.
Last Year at Marienbad is a 1961 French film, consider a classic by some and a turkey by many, which features a man and a woman meeting at a chateau and arguing about whether they met at Marienbad a year ago.
Look look look. Starsky and Hutch.
Starsky and Hutch are the two lead detectives in the ABC 70s TV series Starsky & Hutch
Rizzoli and Isles.
Rizzoli and Isles are a police detective and a medical examiner who team up, on the TNT series Rizzoli & Isles
Sam: Special Agent Rose, and this is Special Agent Hudson.
Axl Rose and Saul Hudson (Slash) play with Guns N' Roses.
I know you two idiots are gonna go shoot cut scenes for Jackass
(2000-02) is a MTV TV series where guys attempt dangerous stunts and pranks.
Michael: It's like Dumber & Dumber 3.
Dumb and Dumber is a 1994 comedy movie about two idiots who travel across country to help one of them end up with the woman of his dreams.
Are you an X-File?
is a 1993-2002 Fox TV series about two FBI agents who investigate "x-file" case involving the supernatural and the alien.
Dean: Not unless you want to put an APB out on Rocky Raccoon.
"Rocky Raccoon" is a 1968 Beatles single, released on the White Album. Despite Dean's comment, it has nothing to do with raccoons: the main character is named Rocky Raccoon.