Dean: Did you get any sleep last night?
Sam: Yeah, I got a couple of hours.
Dean: You're a liar. See, I was up at 3 and you were watching the George Foreman infomercial.
Sam: What can I say, it's riveting TV.
Sam: Never? You're never afraid?
Dean: No, not really.
(Sam pulls the long knife out from underneath Dean's pillow)
Dean: That's not fear. That's precaution.
Sam: Yeah, he told me. It was a poltergeist?
Co-Worker: (overhearing) Poltergeist? Man, I love that movie!
Jerry Panowski: Hey, no one's talking to you. Keep walkin'.
Sam: Homeland Security. It’s pretty illegal, even for us.
Dean: Yeah, well, it’s something new. You know, people haven’t seen it a thousand times.
Dean: (on his Homeland Security disguise) Man, I look like one of the Blues Brothers.
Sam: No you don't. You look more like a seventh grader at his first dance.
Sam: What is that?
Dean: It's an EMF meter. It reads electromagnetic frequencies.
Sam: Yeah, I know what an EMF meter is. But why does that one look like a busted-up Walkman?
Dean: (smugly) Because that's what I made it out of. It's homemade.
Sam: Yeah, I can see that.
Amanda: This is Amanda Walker.
Dean: Miss Walker. Hi! This is Doctor James Hetfield from St. Francis Memorial Hospital. We have a Karen Walker here.
Amanda: My Karen?
Dean: Nothing serious, just a minor car accident, but she was injured so...
Amanda: Wait, wait, that is impossible. I just got off the phone with her.
Dean: You what?
Sam: Are you okay?
Dean: No, not really.
Sam: Why? What's wrong?
Dean: Uh, I kind of have this problem with...
(makes flying gesture)
Dean: It's never really been an issue until now.
Sam: You're joking, right?
Dean: Do I look like I'm joking?!? Why do you think I drive everywhere, Sam?!
Sam: Are you humming to Metallica?
Dean: Calms me down.
Sam: If she's possessed, she'll flinch at the name of God.
Dean: Uh, nice.
Sam: Say it In Latin.
Dean: I know!
Sam: Uh, in Latin it's "Cristo."
Dean: Dude, I know! I'm not an idiot!
Dean: Sam, this plane is going to crash, okay? So quit treating me like I'm freakin' four!
Sam: You need to calm down.
Dean: Well, I'm sorry. I can't!
Sam: Yes, you can.
Dean: Dude, stow the touchy-feely, self-help-yoga crap. It's not helping!
Dean: Maybe the thing's just not on the plane.
Sam: You believe that?
Dean: Well, I will if you will.
Dean: All right, this is gonna sound nuts, but we just don’t have the time for the whole the-truth-is-out-there speech so...
Dean: Man, I look like one of the Blues Brothers.
In the movie Blues Brothers, the main characters wore black suits, black hats, and sunglasses.
Dean: Hi, This is Dr. James Hetfield.
James Hetfield is the lead singer of the band Metallica, whose music is often used in the series.
Sam and Dean make several references to Flight 401, a plane that crashed in the Everglades in December of 1972 and its parts were re-used in other planes. In the planes with 401's parts, sightings of the ghosts of the pilot and the co-pilot were often reported.
Dean: This goes way beyond floating over a bed or barfing pea soup.
Dean is referencing the 1973 film The Exorcist in which a young girl becomes posessed.
Dean: We don't have time for "the-truth-is-out-there" speech, so...
This is a reference to The X-Files, in which at the end of the opening sequence, this phrase is seen on the screen.