This episode was originally entitled "Afterlife".

Jared Padalecki (Sam) broke his wrist while filming a stunt for this episode, forcing the writers to write an injury, which was Sam being tackled by a zombie, into the story in order to explain Sam's cast.

John's dog tags read:
Winchester
John
306-00-3594
Type - AB
Non Religious

Dean: Come on, Sam, I’m begging you. This is stupid.
Sam: Why?
Dean: Going to visit Mom’s grave? She doesn’t even have a grave. There was no body left after the fire.
Sam: She has a headstone.
Dean: Yeah, put up by her uncle, a man we’ve never even met. So you wanna go pay your respects to a slab of granite put up by a stranger? Come on.

Dean: Why don’t we swing by the Roadhouse, instead? I mean, we haven’t heard anything on the demon lately. We should be hunting that son of a bitch down.
Sam: hat’s a good idea. You should. Just drop me off, I’ll hitch a ride, I’ll meet you there tomorrow.
Dean: Right. I’ll be stuck with those people, making awkward small talk til you show up. No thanks.

Sam: Okay. So what are you thinking?
Dean: I don’t know, unholy ground, maybe.
Sam: Un…
Dean: What? If something evil happened, it could easily poison the ground. Remember the farm outside Cedar Rapids?
Sam: Yeah.
Dean: Could be the sign of a demonic presence. Or the Angela girl’s spirit, if it’s powerful enough. (Sam walks away) Well, don’t get too excited, you might pull something.

Sam: Burn the bones? Are you high?

Dean: Sam, you bring Dad's death up one more time, I swear...
Sam: Please, Dean, it's killing you. Please. We've already lost Dad, we've lost Mom, I've lost Jessica. And now I'm gonna lose you too.
Dean: We better get out of here before the cops come. I hear you, okay? Yeah, I'm being an ass, and I'm sorry. But right now, we got a freaking zombie running around, we need to figure out how to kill it. Right?
Sam: Our lives are weird, man.
Dean: You're telling me. Come on.

Dean: We can't just waste it with a head shot?
Sam: Dude, you've been watching way too many Romero flicks.
Dean: You're telling me there's no lore on how to smoke 'em?
Sam: No, Dean, I'm telling you there's too much! I mean, there's a hundred different legends on the walking dead but they all have different methods for killing them. Some say setting them on fire, one said... where is it? Right here: feeding their hearts to wild dogs--that's my personal favorite.

Dean: I think if it's not her dad, then it might be that guy Neil.
Sam: Neil?
Dean: Yep.
Sam: How'd you come up with that?
Dean: You got your journal, I've got mine. (reading Angela's diary) "Neil's a real shoulder to cry on, he's so understands what I'm m going through with Matt." There's more here where that came from, it's got unrequited Ducky love written all over it.
Sam: Yeah, but that doesn't mean he brought her back from the dead.
Dean: Hmm, did I mention he's Professor Mason's TA? Has access to all the same books.

Dean: Neil! It's your grief conselors. We've come to hug.

Sam: Silver bullets?
Dean: Yeah, enough to make her rattle like a change purse.

Sam: You think Angela's going after somebody?
Dean: Nah, I think she went out to rent Beaches.

Dean: She clipped Matt because he was cheating, right?
Sam: Yeah.
Dean: Well, it takes two to, you know, have hardcore sex.

Dean: Damn, that dead chick can run.

Dean: I've heard of people doing some pretty desperate things to get laid, but you take the cake.

Neil: You're crazy.
Dean: Your girlfriend's past her expiration date and we're crazy?

(after burying Angela)
Sam: Rest in peace.
Dean: Yeah, for good this time, okay?

Sam: But did we have to use me as bait?
Dean: I figured you were more her type. I mean, she had pretty crappy taste in guys.
Sam: I think she broke my hand.
Dean: You're just too fragile. We'll get it looked at later.

Dean: I never should have come back, Sam. It wasn’t natural and now look what's come of it. I was dead and I should have stayed dead. So tell me, what could you possibly say to make that all right.

Dean: I never should have come back, Sam. It wasn’t natural and now look what's come of it. I was dead and I should have stayed dead. You wanted to know how I was feeling. Well, that's it. So tell me, what could you possibly say to make that all right?

Episode Title: Children Shouldn't Play With Dead Things

Children Shouldn't Play With Dead Things is the title of a 1972 horror movie starring Alan Ormsby and Valerie Mamches about a group of six actors who perform a ritual on an island that causes zombies to return from the dead.

Dean: It's got unrequited "Duckie" love written all over it.

Duckie is a character from the popular '80s movie Sixteen Candles played by Two and a Half Men's Jon Cryer. In the movie, Duckie constantly pines over Molly Ringwald's character, Samantha Baker, who happens to be Duckie's best friend.

Sam: I think you have watched too many Romero movies.

Sam is referring to writer and director George A. Romero, who has written and directed several horror and zombie movies including Dawn of the Dead and Night of the Living Dead.

Alan Stanwyk

Dean's pseudonym, Alan Stanwyk, is a character from the Gregory Mcdonald novel Fletch.

Angela: Hi, Lucy, I’m home!

Angela is quoting the famous line spoken by Ricky to Lucy when he comes home in the television series I Love Lucy.

Sam: You think Angela's going after somebody?
Dean: No, I think she went out to rent Beaches.

Beaches was a 1988 tear-jerking "chick flick" starring Bette Midler and Barbara Hershey.

Necromancy

Necromancy, the act of bring up the dead in order to gain knowledge about future events, comes from the Greek root words nekrós, "dead", and manteía, "divination". Historically, Necromancy was used to summon a spirit in order to ask about the future, not bringing to life one that has passed as depicted in this episode.