Dean: What does that mean? I'm not gonna waste an innocent man. I wouldn't!
Sam: I never said you would.
Sam: Fine. Look, we don't know what it is. But whatever it is, that guy in the chair is a part of it. So let's find him, and see what's what.
Sam: Roanoke? Lost colony? Ring a bell? Dean, did you pay any attention to history class?
Dean: Yeah. The shot heard 'round the world, how bills become laws....
Sam: That's not school; that's Schoolhouse Rock!
Sam: I hesitated, Dean. It was a kid.
Dean: No, it was an It.
Dean: I’m gonna go down there, see if I can find some help. My partner’ll stick around, keep you guys safe.
Dr. Amanda Lee: Safe from what?
Dean: We’ll get back to you on that.
Barricade Guard: Say, why don't you get out of the car and we'll talk a little?
Dean: Well, you are a handsome devil, but I don't swing that way. Sorry.
Dean: Put it down!
Sarge: Are you one of them?!
Dean: No, are you?!
Dean: You could be lying!
Sarge: So could you!
Dean: All right, all right. We could do this all day, all right, let's just, uh, let's take it easy before we kill each other.
Sarge: My neighbor, Mr. Rogers…
Dean: You’ve got a neighbor named Mr. Rogers?
Sarge: Not anymore.
Dean: (as Dean and Sarge point their guns at each other) Well, this ought to be a relaxing drive.
Duane Tanner: You were gonna shoot me!
Dean: You don't shut your pie hole, I still might!
Dr. Amanda Lee: I'm sorry. Thanks for everything, Marshals.
Dean: Oh, actually we're not really marshals.
Dr. Amanda Lee: Um, oh.
Dean: Wish we had a deck of cards, a Foosball table, or something.
Sam: Dean, don't do this. Just get the hell out of here.
Dean: No way.
Sam: Dean, gimme my gun and leave!
Dean: For the last time, Sammy. No.
Sam: This is the dumbest thing you’ve ever done.
Dean: I don’t know about that. Remember that waitress in Tampa? Brrr....
Sam: It’s over for me. It doesn’t have to be for you.
Sam: No. You can keep going!
Dean: Who says I want to?
Dean: I’m tired, Sam. I’m tired of this job, this life, this weight on my shoulders, man. I’m tired of it.
Dean: I just think maybe we ought to go to the Grand Canyon.
Dean: Yeah, you know, all this driving back and forth cross country, you know, I've never been the Grand Canyon. Or we could go to TJ, or Hollywood, see if we could bang Lindsay Lohan.
Dean: You've got a neighbor named Mr. Rogers?
Fred Rogers, known as Mr. Rogers, is the star of the children’s series Mister Rogers Neighborhood.
Dean: Billy Gibbons, Frank Beard, U.S. Marshalls.
Billy Gibbons and Frank Beard are members of the band ZZ Top.
Dean: That was creepy. A little too Stepford, right?
In the 1975 film The Stepford Wives, which was remade in 2004, tells the story about a town in which women are replaced as robots in order for them to be the perfect wives.