Dean: See? Nothing to worry about.
Sam: Yeah, being fugitives. Freakin' dance party.
Dean: Hey, man, chicks dig the danger vibe.

Dean: My god, Barbara Eden was hot, wasn’t she? And way hotter than that Bewitched chick.
Sam: Are you even listening to me?
Dean: Umm, yeah.

Dean: The Djinn, it attacked me.
Sam: The gin? You were drinking gin?
Dean: No, ass-hat, the Djinn, the scary creature, remember?

Dean: Let me ask you a question. When you put me into bed when I was little, what did you always tell me?
Mary: Dean, I don't understand.
Dean: Just answer the question.
Mary: I told you angels were watching over you.
Dean: I don't believe it.

Professor: Son? You been drinking?
Dean: Everybody keeps asking me that. But, uh, no.

Dean: That lawn looks like it could use some mowing.
Mary: You want to mow the lawn?
Dean: Are you kidding me? I'd love to mow the lawn.
Mary: Knock yourself out. You'd think you've never mowed a lawn in your life.

Carmen Porter: What do you say later we get you a cheeseburger?
Dean: Oh God yes. How’d I end up with such a cool chick?
Carmen Porter: I just got low standards.

Sam: You know, I'm not asking you to change. I don't know. I guess we just don't really have anything in common, ya know.
Dean: Wait, whoa whoa whoa. Yes we do, Yes we do.
Sam: What?
Dean: Hunting.
Sam: Hunting? I've never been hunting in my life, Dean.
Dean: Yeah, well, then we should go sometime. I think you'd be great at it.

Dean: I'm dating a nurse? That is so... respectable.

Dean: (talking to John's grave) All of them. Everyone that you saved, everyone Sammy and I saved. They're all dead. And there's this woman haunting that's me. I don't know why. I don't know what the connection is. Not yet anyway. It's like my old life is, is coming after me or something, you know? Like it, like it doesn't want me to be happy. Of course, I know what you'd say. Well, not the you that played softball, but... You'd say, "Go hunt the djinn. Hey, it put you here, it could put you back. Your happiness for all those people's lives. No contest, right?" But why? Why is it my job to save these people? Why do I have to be some kind of hero? What about us, huh? What, Mom's not supposed to live her life? Sammy's not supposed to get married? Why do we have to sacrifice everything, Dad?

Sam: Look, whatever stupid thing you're about to do, you're not doing it alone and that's that.
Dean: I don't understand, why are you doing this?
Sam: Because you're still my brother.
Dean: Bitch.
Sam: What are you calling me a bitch for?
Dean: You're supposed to say "jerk."
Sam: What?
Dean: Never mind.

Sam: What's in the bag?
Dean: Nothing.
Sam: Nothing?
Dean: Yeah! Nothing!
Sam: Fine! (grabs the bag)
Dean: You don't want to do that!
Sam: Oh really? What the hell is this?!
Dean: Blood.
Sam: Yeah I can see that it's blood, Dean, but what the hell is it doing in here?!
Dean: You don't really want to know.

Sam: You're having some kind of psychotic breakdown.
Dean: I wish.

Sam: (to Dean, about to stab himself) Look, this isn't a dream, all right. I'm here with you, now, and you are about to kill yourself, Dean.
Dean: No, I'm pretty sure. Like, 90 percent sure. But I'm sure enough.

Dean: You should have seen it, Sam... our lives... you were such a wussy.

Sam: I thought it was supposed to be this perfect fantasy.
Dean: It wasn't. It was just a wish. I wished for Mom to live. Mom never died, we never went hunting, and you and me just never... ya know.
Sam: Yeah. Well, I'm glad we do.

Dean: You had Jess. Mom was gonna have grandkids.
Sam: Yeah, but Dean, it wasn't real.
Dean: I know, but I wanted to stay.

Dean: Ever since Dad... all I can think about is how much this job has cost us. We’ve lost so much; we’ve sacrificed so much...
Sam: But people are alive because of you. It’s worth it, Dean. It is. It’s not fair, and y’know it hurts like hell, but it’s worth it.

While Dean is in the cemetery, his voice is heard but his lips don't move.

When Dean goes to visit Mary he's not wearing a jacket, but when he arrives at her house he has it on.

Episode Title: What Is and What Should Never Be

"What Is and What Should Never Be" is the title of a Led Zeppelin song.

Dean: Well, we're not in Kansas anymore.

Dean is quoting a line from the 1939 movie, The Wizard of Oz.

Dean: My God, Barbara Eden was hot, wasn’t she? And way hotter then that Bewitched chick.

Barbara Eden starred as a genie in the 1960s series, I Dream of Jeannie. In Bewitched, Elizabeth Montgomery starred as Samantha Stephens, a witch.

Dean: Aunty Em? There's no place like home.

Aunt Em and the line "There's no place like home" are both from the 1939 film, The Wizard of Oz.

While Dean is watching television, a memorial for the Flight 424 crash is shown. During "Phantom Traveler", Sam and Dean stop the plane from crashing.

The scene where Dean surprises Sam at Sam's house is word-for-word the same as in the "Pilot" episode.