Ratings: 3.96 million viewers.

Lauren Cohan and Katie Cassidy are no longer series regulars.

This episode marks the first appearance of an angel.

Katie Cassidy's character, Ruby, was recast due to budget cuts.

Bobby: Dean, your chest was ribbons, your insides were slop. And you'd been buried for four months. Even if you could slip out of Hell and inside your meatsuit.
Dean: I know. I should look like a Thriller video reject.
Bobby: What do you remember?
Dean: Not much. I remember I was a hellhound's chew toy. Then lights out. Then I come to six feet under. That was it.

Sam: I tried everything, that's the truth. I tried opening the Devil's Gate. Hell, I tried to bargain, Dean, but no demon would deal, all right? You were rotting in Hell, for months, for months, and I couldn't stop it. So, I'm sorry it wasn't me, all right. Dean, I'm sorry.
Dean: It's okay, Sammy. You don't have to apologize; I believe you.

(seeing Pamela's "Jesse Forever" tattoo)
Dean: So who's Jesse?
Pamela: Well, it wasn't forever.
Dean: His loss.
Pamela: Might be your gain.

Demon Waitress: So you get to just strolled out of the Pit, huh? Tell me, what makes you so special?
Dean: I’d like to think it’s because of my perky nipples.

Dean: Who are you?
Castiel: Castiel.
Dean: Yeah, I figured that much. I mean what are you?
Castiel: I'm an Angel of the Lord.
Dean: Get the hell out of here. There's no such thing.
Castiel: This is your problem Dean, you have no faith.

Episode Title: Lazarus Rising

In the Bible, Lazarus was a man who Jesus rose from the dead after being in his tomb for four days.