The episode ends with a musical video/outtake of Jensen Ackles singing along to "Eye of the Tiger" by Survivor, as the crew applaud.

Coroner: Everyone drops dead sooner or later. That’s why I’ve got job security.

Coroner: Oh, sorry. Spleen juice.

Sheriff Britton: Me and Frank, we were friends. Hell, we were Gamecocks. (Dean snickers) That’s our softball team’s name.
Dean: Mmm.
Sheriff Britton: They’re majestic animals.

Sam: Dude, you're going twenty.
Dean: And?
Sam: That's the speed limit.
Dean: What? Safety's a crime now?
Sam: Dude, where are you going? That was our hotel.
Dean: Sam, I'm not gonna make a left-hand turn into oncoming traffic, I'm not suicidal. (thinks about it) Did I just say that? That was kinda weird.

Sam: It’s ghost sickness.
Dean: Ghost sickness?
Sam: Yeah.
Dean: God, no.
Sam: Yeah.
Dean: I don’t even know what that is.

Sam: We've been completely ignoring the biggest clue we have… you.
Dean: I don't want to be a clue.

Dean: I mean, come on, we hunt monsters. What the hell?!? I mean, normal people, they see a monster and run. No, no, we search out things that want to kill us. Yeah? Huh? Or eat us! You know who does that? Crazy people! We… are insane. You know, then there’s the bad diner food and then the skeevy motel rooms and the truck-stop waitress with the bizarre rash. I mean, who wants this life, Sam? Huh? Seriously? Do you actually like being stuck in a car with me eight hours a day, every single day. I don’t think so. I mean, I drive too fast and I listen to the same five albums over and over and over again and, and I sing along and I’m annoying, I know that. And you… you’re gassy. You eat half a burrito and you get toxic! I mean, you know what? You can forget it.