Season 1 |
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| 6 :01x06 - Jerry Seinfeld (Oct/21/2006) | | Former “Seinfeld” scribe Spike Feresten interviews his old boss Jerry Seinfeld, who also performs a stand-up routine titled “What's Nuts Now?” | | Guest Stars: Jerry Seinfeld as Himself | |
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| 11 :01x11 - Cheryl Hines (Dec/09/2006) | | Cheryl Hines is interviewed and chugs a beer. Sketches include “Heckler Whisperer” and “Morbidly Obese Aquarium.” | | Guest Stars: Cheryl Hines as Herself | |
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| 16 :01x16 - John C. McGinley (Feb/10/2007) | | John C. McGinley (“Scrubs”) joins Spike for conversation and sketches. Included: Spike gets a women's health update and examines U.S. relations with North Korea; and a sketch features a senior transsexual party for stoners. | | Guest Stars: John C. McGinley as Himself | |
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| 18 :01x18 - Bobby Lee (Feb/24/2007) | | Bobby Lee (“Mad TV”) is the guest. Comedy bits include a publicity-photo challenge and a skit called “Horrifyingly Sexy Hannity and Colmes.” | | Guest Stars: Bobby Lee (10) as Himself | |
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| 19 :01x19 - Seth MacFarlane (Mar/24/2007) | | Seth MacFarlane, creator and executive producer of “Family Guy” and “American Dad,” is the guest. Included: vintage footage from the “Donny Riffle” talk show and a sketch about “Fabreze Elderly.” | | Guest Stars: Seth MacFarlane as Himself | |
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| 20 :01x20 - Alex Borstein (Apr/07/2007) | | Alex Borstein (“Family Guy”) joins Spike for sketches about answering Dr. Phil's fan mail and announcing a new “back fat” sponsor. | | Guest Stars: Alex Borstein as Herself | |
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Season 2 |
| 23 :02x01 - Ryan Seacrest (Sep/15/2007) | | In the second-season premiere, Feresten visits Ryan Seacrest at the San Diego “American Idol” auditions. Sketches include an installment of “Comedy for Stoners” and a bit about homeland security set in Venice Beach. | | Guest Stars: Ryan Seacrest as Himself | |
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Season 3 |
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