George Takei, Chelsea Handler, Tom Green, and Shannon Elizabeth take the stage this week, competing to make their scenes this week's funniest.
Paul Rodriguez, Kurtwood Smith, Ana Gasteyer, and Nicole Sullivan are thrust into bizarre situations and compete to be this week's funniest.
Tonight, Wayne Knight, Bill Bellamy, Eddie Kaye Thomas and Wendie Malick. compete on the scriptless set of of "Thank God You're Here." Jerry Springer also makes a surprise guest appearance.