George has a very important dinner for the abortion summit meeting with both the pro life and pro choice leaders being present. Unfortunately it happens to be the same night he made dinner plans with his wife, Laura. George's attempts to persuade Laura to move the date fail and he's forced to hold both meetings, simultaneously, without letting Laura find out.
Having made a promise to his frat buddies in college that if he ever became President they could move in to the White House, George quickly has to tell them to leave. They ask for one more night of partying with him, but he has to attend a highly publicized execution, so George has Karl hire an improv-group to act out a fake execution.
Upon seeing how high his phone bill is, George questions his wife, Laura, to see who she's been calling. Turns out she's hooked on tarot card readings, and George quickly becomes addicted too. Their psychic draws a death card and George begins to fear he is under attack, so he bans all guns in America. An angry mob forms at the White House and George gets a visit from Charlton Heston.
George is having trouble getting his TV company to install cable in the White House, so his neighbor Karl offers to wire the cable box for him. While hooking the cable up, Karl connects the wrong wires and causes a temporary power outage. This makes the new S.D.I. layer system installed in the Oval Office fire at Austria, who quickly retaliates.
The White House residents celebrate the twenty-fourth birthday of George and Laura's pet cat, Pun'kin. Unfortunately the cat is very sick and George decides to have it put to sleep. At the same time, Laura begins to think there is something wrong with her because she and George no longer make love. This leads to a misunderstanding as to which pussy needs to go.
The 100,000,000th drug offender is caught and then brought to the White House. They plan an event to have Laura and George's Mom make the arrest, live on TV. Laura plans and prepares the event, but George's Mom keeps interfering with them. After confronting his mother about letting Laura plan the event, George mistakes the Ecstasy pills they took from the drug offender as aspirin, and the live ceremony is only a few hours away.
As protesters gather outside the White House in response to oil drilling in Alaska, Laura sets Karl up on a date with her friend. After Karl falls in love with his new love interest, he admits to having a wife and daughter that he no longer cares for. He also has no interest in his job, making George's life a nightmare, especially when he needs to deliver a speech to the protesters.
After losing the Middle East peace treaty, the Vice President, Dick Cheney tells George that he should step down from office before the Senate impeaches him. He accepts and moves out with Laura, but has trouble finding a steady job because he keeps getting fired. Fortunately, he find success wrestling as 'The Mysterious Loser'.