This is one of the rare episodes where the shrill voice of Mrs. Wolowitz is heard outside of her home.
It takes the obese Mrs. Wolowitz 30 minutes to climb up the four flights of stairs to Leonard and Sheldon's apartment.
The title refers to the conflict Sheldon faces between a weekend of playing video games versus attend the birthday party of Amy's aunt and meeting her relatives.
Leonard: I'd make fun of Sheldon for having girl problems, if I wasn't shocked that Sheldon has girl problems.
Amy: I'm dating Sheldon Cooper.
Penny: Yes, and on purpose.
Amy: He's handsome, he's lanky, he's brilliant, and his skin has that pale, waxy quality.
Penny: Well, sickly is the new sexy.
Penny: (to Leonard) Sorry, stallion. Your weird friend giraffe is here.
Mrs. Wolowitz: (outside the door) Howard Joel Wolowitz! I've been worried sick for two days and I know you turned off your phone! You open this door right now because I've had it up to here! I've been to the morgue and the hospital and I've spent the last half hour walking up these ferkakta stairs!
Howard: Gotta go. That's my ride!
Howard: (to Sheldon) You're a grown man! Act like one. Tell Amy you wanna spend the weekend having a sleepover and playing video games with your friends.