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Season 4

37 :04x01 - Quality of Life

Apr/29/2013
Cathy plans Adam's sixteenth birthday party. Andrea struggles settling in with her new room-mate at fashion school. Paul brings in a new assistant.
Special Guest Stars: Phyllis Somerville as Marlene |
Guest Stars: Kathy Najimy as Therapist | Brandon Tyler Harris as Ralph | Liz Holtan as Amber | Emily Tremaine as Dina | Michael Ray Escamilla as Angel | Samantha Futerman as Lydia Hye | Alan Alda as Dr. Atticus Sherman | Connie Ray as Principal Connie Schuler | Roslyn Ruff as Nurse | Heather MacRae as Stephanie | Emma Noble as Amanda |
Uncredited: Booch O'connell as Restaurant Patron
Director: Michael Engler
Writer: Darlene Hunt

38 :04x02 - You Can't Take It With You

May/06/2013
Sean feels inspired to donate to charity. Cathy upsets Paul when she signs him up to an online dating service. Andrea struggles to impress her tutor, Isaac Mizhari.
Special Guest Stars: Isaac Mizrahi as Himself |
Guest Stars: Samantha Futerman as Lydia Hye | Kathy Najimy as Therapist | Mary Joy as Marcy | Jesse Newman as Hollis | Emily Tremaine as Dina | Sujoy De as Store Worker | Bianca Amato as Susan Rand | Peter Bartlett as Himself | Brandon Williams as Himself | Jessica Dickey as Brenda | Jordan Simmons as Hostess | Neema Atri as Quirky Art Student | Wendy Rich Stetson as Waitress |
Uncredited: Annika Merkel as Thrift Store Shopper
Director: Jann Turner

39 :04x03 - Quality of Death

May/13/2013
Dr. Sherman pays Cathy a visit who has checked herself into a hospice and is experiencing problems with her new room-mate. Adam confronts Paul about his lack of parental guidance. Andrea seeks inspiration from Cathy.
Special Guest Stars: Isaac Mizrahi as Himself |
Guest Stars: Kathy Najimy as Therapist | Liz Holtan as Amber | Jesse Newman as Hollis | Michael Ray Escamilla as Angel | Tom Morrissey as Sid | Jennifer Mudge as Nurse Valerie | Christian Massa as John | Dana Ivey as Herself | Alan Alda as Dr. Atticus Sherman | Darlene Hunt as Hospice Adminastrator | Bianca Amato as Susan Rand | Angela Wyndham Lewis as Day Nurse | Tijuana Ricks as Day Nurse | Kyle Beltran as Jose | Lee Aaron Rosen as Cop | Les J.N. Mau as Hiro | Emily Mechier as Young Nun |
Uncredited: Dennis Michael Giammetta as Fashion Spectator
Director: Richard Heus
Writer: Jenny Bicks

40 :04x04 - The Finale

May/20/2013
Adam surprises everyone when he fulfils one of Cathy's wishes. Cathy's estranged Dad visits her. Andrea gets the opportunity of a lifetime. Sean has mixed feelings about his impending kidney surgery.
Special Guest Stars: Isaac Mizrahi as Himself | Phyllis Somerville as Marlene |
Guest Stars: Kathy Najimy as Therapist | Michael Ray Escamilla as Angel | David Aaron Baker as Priest | Ramsey Faragallah as Imam | Judy Gold as Rabbi | Darlene Hunt as Hospice Adminastrator | Brian Dennehy as Dad | Connie Ray as Principal Connie Schuler | Bianca Amato as Susan Rand | Marceline Hugot as Ina | David Wilson Barnes as Wesley | David Andrew MacDonald as Ray Milson | Marin Mazzie as Janelle Milson | Jen Sese as Florist |
Uncredited: Rosemary Howard as Hospital Visitor
Director: Michael Engler
Warning: The Big C guide may contain spoilers
Classification: Scripted
Genre: Comedy | Family
Status: Ended
Network: SHOWTIME ( USA)
Airs: Mondays at 09:00 pm
Runtime: 30 Minutes
Premiere: August 16, 2010
Ended: May 20, 2013
This guide is currently edited by:
TomSouthwell (Challenge)

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