One of the FBI's most wanted fugitives, Raymond "Red" Reddington turns himself in to the FBI with a list of the worst criminal nightmares that nobody knows about. Brand new profiler Elizabeth Keen's first day is a mess of questions leading to questions when this mysterious man decides that she's the only person he'll talk to. There's no time for the answers when a dead terrorist puts them on a short timeline.
After Red correctly predicts a catastrophe caused by an assassin called "The Freelancer", he and Liz go undercover to save his next target. Ressler and their CIA liaison, Meera Malik are left to try to keep an eye on them from the distance.
Red helps the FBI hunt down a high-ranking Chinese spy, Wujing, who has hired Red to help decode a classified CIA transmission. Liz, who poses as an FBI cryptographer goes with Red to decode the message.
After being forced to testify against a drug trafficker, Hector Lorca, the witness is abducted. Red informs the FBI that "The Stewmaker", a guy who has managed to stay under the radar after hundreds of abductions, is in town. Things get out of control forcing Red and Ressler to work together.
Red informs the FBI that "The Courier", a dangerously reliable middle man, is delivering a package to an Iranian spy. While trying to stop the mysterious transaction Liz gets thrust into a kidnapping plot.
Tom claims to be innocent and insists that they turn the box into the FBI to clear his name. Meanwhile, Red brings forth the next name on the blacklist, Gina Zanetakos, a deadly corporate terrorist.
Liz and the FBI search the man responsible for a chemical attack on a subway. She reluctantly calls on Red for help. Things get more complicated in Liz's life after Red tells her not to trust Tom.
The next name on the blacklist leads Liz to discover an elaborate plot to destroy the countries financial system. When a family member falls ill, it's Tom who supports Liz.
Ressler's attempt to protect Red from an assassination attempt proves to be misguided. Anslo Garrick puts himself on the blacklist by infiltrating the "post office" in an attempt to capture Red. Liz spends the raid trapped in an elevator with no idea what's going on.
Liz infiltrates the black site and manages to call in backup, but gets into trouble along the way. Red tries to bargain with Anslo Garrick while people on both sides of the cage die.
The entire FBI team is investigated by internal affairs after a mole helped Anslo Garrick infiltrate the "Post Office". Red has gone missing and conducts his own investigation into who betrayed him. A serial killer from Liz's past, "The Good Samaritan", strikes again. Agent Cooper lets her go on the hunt hoping that such an important case will help lure Red out of hiding.
Red brings "the Alchemist", a killer who uses science to transform people's DNA, to the FBI's attention. He's been hired to protect a mob informant and his wife, leaving bodies behind. Meanwhile, Liz and Tom hit another bump in their relationship.
In line with her own planning, Red shows Liz an crooked adoption agency. She has to follow the line of missing women while contemplating adopting a child of her own.
Red reveals a woman from his past, Madeline Pratt is the next target on the list. Liz helps Tom come to terms with their impending adoption. At an elaborate party at the Syrian Embassy, Red manages to convince Liz to pull off a heist.
-- Rawnald Gregory Erickson the Second
After having been missing for 12 years a prominent prosecutor is found. Red believes a underground judge, Ruth Kipling, is behind the murder and investigates the idea of the killer, previously assumed to of been a myth. The rumors about the myth suggest that an underground criminal appeals process see's that those who have wrongfully imprisoned or punished someone in the past, be punished themselves. Tom is tempted by a woman at a teachers conference in Orlando and Red does a background check on her.
Mako Tanida a past associate of Red's jumps to the front of the blacklist when he escapes from prison and targets Ressler. Tom's plans flesh out as he confronts Jolene.
A Russian cyber terrorist known only as Ivan is suspected when a defense asset is stolen online. Liz and Red manage to uncover a huge cover up. New evidence comes to light in the case of Jolene's disappearance which in turn helps in the case of the mystery surrounding Tom.
Red sets the team onto the hunt for "The Undertaker", a mercenary who convinces ordinary people to conduct contract killings. Meanwhile Liz is finally ready to work with Red on Tom's secrets.
The extraction team who worked for Ranko Zamani besting the FBI are back to take a Chinese scientist. Even after sicking the FBI onto them, Red has a job of his own for the team of brothers.
A politician in Prague finds himself being framed for murder, which sees the team attempting to take down the Kingmaker, a strategist who's behind the emergence of some powerful politicians.
Liz now knows the truth about her father and refuses to work with Red. Red brings a compelling case to the FBI. Liz reveals what she has learned about Tom's life.
-- Anonymity is The New Flame, Depeche Mode
-- Sooth My Soul (Joris Delacroix Remix)
A mysterious plane crash involving prisoners causes a city wide lock down. The manhunt requires Red's assistance, but he has been moved and custody of him taken from "The Post Office". The stakes get even higher when it's revealed that "Berlin" was on the plane.