| Name (Sort) | Character (Sort) | |
| •Jeremy Irons | played | Rodrigo Borgia (22Eps.) |
| •Aidan Alexander | played | Joffre Borgia (9Eps.) |
| •Colm Feore | played | Cardinal Della Rovere (16Eps.) |
| •David Oakes | played | Juan Borgia (17Eps.) |
| •Derek Jacobi | played | Cardinal Orsini (3Eps.) |
| •François Arnaud | played | Cesare Borgia (22Eps.) |
| •Holliday Grainger | played | Lucrezia Borgia (22Eps.) |
| •Joanne Whalley | played | Vanozza (17Eps.) |
| •Lotte Verbeek | played | Giulia Farnese (18Eps.) |
| •Sean Harris | played | Micheletto (17Eps.) |
| •Simon McBurney | played | Johannes Burchart (4Eps.) |