At first, Kuzco fakes being sick, but later is really sick after Yzma gives him one of her potions.
Bucky the Squirrel from the movies, The Emperor's New Groove and Kronk's New Groove, makes a special appearance.
Kuzco: Do you think I'm going to save someone's life by saying Squeak Squeak Squeakers?
Mr. Moleguaco: I doubt it. Because you said, "Go jump in a shark tank."
Kuzco: Get out of the way! A mango cart is going to squash you!
(Bucky stares at him)
Kuzco: Stupid squirrel doesn't understand English.
(Yzma thinking of evil plan)
Yzma: I know! I'll climb the highest mountain, and put a snow potion in the clouds. Then, it'll snow on the mountain. And they'll have snowball fights. And build snowmen. And drink hot chocolate. And make snow angels. It's a winter wonderland!
Kronk: Sounds like fun!
Yzma: Fun? We don't want to have fun!
Kuzco: I'm sick. Somebody call a bank!