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While Martinez lies at death's door, Jarvis becomes Acting President and faces dual crises: Sterling confirms his involvement in Martinez's poisoning, and Sophia threatens him if he doesn't allow the importation of her WMD into the U.S. Meanwhile, Michael and Leila try to free Simon, while Sean and Vicky try to find the courier carrying the bioweapon.
Sophia: Do you know what scares me the most?
Michael: No, what?
Sophia: The letting go... of who I used to be. I knew that it would be painful to follow through on Thomas’ plan, that in order to make room for our people here, to ensure their survival, I would have to… sacrifice some of my principals.
Michael: Well, you’ve taken a huge burden on your shoulders, Sophia.
Sophia: But that doesn’t make what needs to happen next any easier.
Michael: Now I have to go.
Leila: When I was a kid, I was playing with the boys across the street, and they killed a bird. I told you what happened, and you said we were the strongest and smartest things on the planet, so we had a responsibility to protect the smaller, weaker things, because if we didn’t do it, that no one else would. That it was the right thing to do. I don’t know if you remember that, but I do. And I’m looking at you, and I don’t recognize that person anymore.