Due to a nuclear explosion caused by Dr. Doom, the Fantastic Four do not have their powers anymore. Meanwhile, Dr. Doom makes an attempt to take over the Baxter building. Now, the Fantastic Four will need the help of Daredevil to reclaim the Baxter building and regain their powers.
Gorgon is looking for Medusa, so that he can return her to the great refuge. Human Torch is then forced to help her, but Gorgon manages to capture Medusa. Then the Fantastic Four end up learning the location of his hideout.
Reed Richards discovers a strange goop that can effect people’s emotions. The goop originates from the Micro Verse, and it belonged to Psycho Man, who wants it back.
There are dozens of Natural disasters occurring all around the world, so the Fantastic Four travel to space with hopes of finding the source of all their problems. It turns out that a being known as Ego is behind it all and Thor and the Fantastic Four can’t defeat it by themselves, so they must call on Galactus.
Black Panther lures the Fantastic Four to Africa, where the FF discover that Black Panther is the leader of a tribe, and the tribe is under attack by a being known as Klaw. Can the Fantastic Four help Black Panther and his tribe defeat Klaw?
Johnny is depressed over Crystal, and he ends up meeting a girl who has powers identical to his own. Meanwhile Terrax is causing trouble in Manhattan, and he demands that the Fantastic Four fight Galactus.
Bruce Banner comes to Reed Richards, with hopes that Reed can help him cure the curse of being the Incredible Hulk. However, Bruce ends up turning into the Incredible Hulk and going on a rampage. Can the Fantastic Four stop Hulk from destroying the city?
Sue is in need of life saving surgery that only her father can perform. Sue’s father is then arrested after the surgery because he is being accused of a murder. Then, the Skrulls release Super Skrull who takes his place, with plans of extracting his revenge.
Super Skrull goes after the Impossible Man. Johnny then agrees to protect him if he gets Lockjaw to teleport him to the General Refuge, so that Johnny can visit Crystal.
Guest Stars: Jess Harnell as Impossible Man/Super Skrull
Johnny is reunited with Crystal as Black Bolt destroys the negative barrier and frees the Inhumans. Meanwhile, Mr. Fantastic, The Thing, and the Invisible Woman head to Tee Vu Island.
Dr. Doom takes over Silver Surfer’s powers once more, and it is up to the Fantastic Four to take Doom down and give Silver Surfer his powers back… again.
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