Dr. Richard Kimble begins his run from the law by heading to Tucson, Arizona, where he checks into a hotel and takes on a job at the Branding Iron as a bartender. While there he befriends the piano player, Monica Welles, who is being stalked by her estranged husband.
Richard heads off to a backwater town in Missouri, where he meets a young girl named Jenny. Although they become friends, Jenny is a pathological liar who manages to get him in trouble by using him as an excuse for her being late for school by saying he attacked her. When Richard show up at the school as a deliveryman, Jenny points him out as her attacker. Jenny's teacher has a talk with him and explains about Jenny's lying habit. But she now gets her teacher and Kimble in trouble again by saying she saw them kissing. When Richard attempts to clear up the situation the town turns against him and makes plans to hang him.
While in West Virginia, Richard is beaten by the local blue collar workers of the coal mining town, and then ran out of town by the sheriff. Kimble runs off into the mountains where he meets a young woman named Cassie, who lives in a cabin with her grandmother. Although she says she will help him to safety, she really is intent on keeping him around. Meanwhile, Gerard has been alerted by the sheriff that Kimble has been sighted in the area.
Kimble is now in Santa Barbara, California, working as an apprentice sail maker. He falls in love with the boss' niece Karen, but is quickly given a warning by her brother to stay away. Suddenly, his boss Lars suffers a fatal heart attack and requests that Richard takes care of Karen. Meanwhile, Gerard hopes to catch Kimble by posting a story in the newspaper of a one armed robber being caught in Los Angeles.
Kimble escapes Gerard's men after discovering the one armed robber was not the same man he had seen fleeing his home on the night his wife was murdered. Richard heads back to Santa Barbara to lay low with Karen, only to have left behind a clue for Gerard of his whereabouts. Kimble convinces Karen to sail off with him to escape Gerard and then fake their own deaths as having drowned.
Kimble get employed as a cut man for a black boxer named Joe Smith, who Richard believes is losing his memory due to brain injuries from fighting. A police detective, Henry Stone, is set to investigate a possible case of mob connections for Joe's manager, but finds a bigger fish when he meets Richard Kimble.
Richard is now employed at a farm labor camp and is about to blow his cover when he opts to help a woman at the camp deliver her baby, since the access to the hospital is blocked by a forest fire. Gerard gets word of Kimble's act of heroism when a story is written about him in the local newspaper.
Now in New Mexico, working at a gas station, Kimble is taken hostage along with a woman when two men attempt a holdup. The robbers take their hostages with them to Los Angeles, when Richard informs them he is a thief and was headed for a big heist. One of the robbers wants Richard to prove himself to them by killing the woman.
Richard is questioned by an FBI agent who is searching for Korean war criminals while on board small freighter heading to Alaska. When the agent is found murdered the next day, an investigation is conducted and Kimble's phony papers are discovered.
Richard is put in jail by a local sheriff in a small Kentucky town after being involved in a car accident. He is helped by his cell mate in breaking out and hides at his ranch house. Kimble notices that his family treat the slow witted man badly having blamed him for burning down the barn years earlier. Richard vows to prove the man is innocent and finds out Gerard is flying to Kentucky having heard he was seen there.
Richard helps save some children when he comes upon a fiery car crash, and is nursed back to health by a couple who happen to be the local sheriff and his wife. Gerard catches the story of Kimble's heroics on the newswire and is on his way to make his arrest.
Richard has a new job as a stock clerk in a department store and catches his boss accidentally killing his business associate. Kimble makes an anonymous call to his boss when he hears that a homeless man has been blamed for the murder. But instead of a confession, his boss calls a detective to search Kimble's past, believing that he is setting him up for a blackmail scheme.
Kimble, working at a construction site, asks that his supervisor Buck Harmon, hire a mentally challenged young man named Jamie. But when Jamie is accused of sexually assaulting Buck's wife, Richard makes himself Jamie's protector ... especially after the crew foreman arranges a lynch mob to go after the young man.
Richard is nursed back to health by a flight attendant who nearly ran him down with her car. While unconscious, Kimble has reoccurring flashbacks of his wife's murder and his own trial. Ruth, the flight attendant overhears Richard mumbling about his late wife and figures out that he is in some sort of trouble.
Richard heads to his hometown after discovering his father had a heart attack. While hiding out at his sister's home, Kimble feels guilty, believing he has caused his father's condition due to his running from the law, and finds out his brother is convinced that Richard killed his wife and is tired of being chastised for being related to a murderer. Meanwhile, Gerard has gotten the news of the elder Kimble's condition and rushes to his hometown in hopes of finding Richard.
Richard is now in Connecticut working as a ranch hand for a newspaper heiress and her family. He discovers that her sister is having an affair with her husband and is planning to murder her, claiming the fortune for herself. The couple find out that Kimble is on to them and scheme to plant the murder rap on him.
Now in Nebraska, Richard is working on a small farm as a ranch hand. Kimble witnesses the arrest of a man who is being charged with a double murder and is deputized by the sheriff to help transport the man and four witnesses to jail. The man convinces Richard that he is innocent and was just a bystander, but the locals are not buying his story and are preparing to lynch him. But Kimble is left holding the bag when the suspect runs off.
Kimble is now in Reno, Nevada, working in a hotel as a lifeguard. Richard gets caught up in a family squabble between Dan Polichek, the hotel owner and his daughter Chris, who believes caused her mother to leave home and commit suicide. Richard feels sorry for Chris, who is bent on humiliating her dad and uses Kimble as the man she is having an affair with.
Mike Decker, a Chicago newspaper columnist who defended Kimble during his trial is contacted by him when Richard hears that the one armed man is in the city. While on a city wide search, Decker's alcoholic wife falls off the wagon when she finds out what her husband has gotten himself into. Meanwhile, Gerard picks up on Decker's search and uses him to help hunt down Kimble.
Richard is working for Max Bodin, owner of a dog kennel where he breeds award winning Irish Setters. Johnny, Max's son discovers that one of the dogs has a degenerative disease which means the dogs are no longer championship quality. but Johnny sees this as his future and is going to keep his find a secret, that is until Richard uncovers his plan. Now Johnny wants to have Kimble investigated.
Richard is held hostage after a liquor store he is now working at is robbed by a second rate hoodlum, Herbie Grant. Kimble promises Herbie he will help him to freedom if he is let go. But when Herbie is turned in by a maid at a hotel, he believes it is Richard who double crossed him.
Richard is dodging the Nevada police when he helps fix a car and then hitches a ride with Sister Veronica, a nun who is thinking of renouncing her vows. On their way to Sacramento, Veronica decides she wants Richard to stay with her, believing he is her savior.
Richard and Sister Veronica are slowed down by a roadblock and take residence at a ranch, where he is identified by Chuck Mathers, a disgruntled ranch hand. Meanwhile, Veronica sees Richard as being wanted on the TV news, but keeps this fact from him.
Richard, now working as a masseuse, is identified by a local sheriff who wants to run for office. Steve Edson, a co-worker, helps Kimble escape from the sheriff and reveals that he too was wanted for murder, a rap he was acquitted of despite being guilty. Kimble allows Edson to travel with him, a decision which may be a mistake since he has been leaving clues behind in hopes of being caught.
Richard encounters a disfigured man, Joe Hallop, while working at a roller skating rink. Joe recognizes Kimble as the man he saved in the Korean War by shielding him from a grenade. Now Joe wants his revenge and plans on using the only souvenir he has from the war to kill Richard, a live grenade.
Richard is now working at a warehouse, owned by Gus Priamos. Gus recognizes Kimble as being a doctor and tells him he is dying from cancer. Priamos plans to help Richard escape by pretending he has fled to Greece. But when Gus' girlfriend overhears the scheme, she plans on turning him in for the reward.
Kimble needs to find a way to get a kidnapped boy away from his captors after discovering he is a hemophiliac and was injured during the abduction.
Kimble helps out a young wealthy woman who has just been released from a mental hospital, having seen a young boy she was taking care of get mauled by a pack of wild dogs. But her father's new wife wants her to leave their home and plans on making her go insane again by hiring a neighbor to make his dogs bark, a sound that no one else will hear. But Richard has heard the barking and plans on spoiling her plot.
Richard is recognized by a woman who once asked him to perform an illegal abortion. His rejection sent her to a hack doctor who performed the operation and left her barren from now on. The woman's husband is wanted for embezzlement and wants Kimble to drive them to safely from the police or they will turn him in to the authorities.
Gerard sets up a team of detectives after seeing a discarded picture in which places Kimble in Los Angeles. Having set up an 8 mile road block, Richard scampers from place to place where he is constantly recognized. He finally makes his way to a small home which belongs to two homosexuals who have been arguing over Kimble's innocence.
Kimble meets up with a former lawyer, currently a law professor at a small college in Pennsylvania, who claims he could reverse the decision that Richard had received. He agrees to let the professor hold a mock trial with his students which would air on TV, but soon realizes that he is using parts of his own case of how he was disbarred for a drunk driving incident.
A meeting set up with Ellie Burnett, the daughter of Kimble's defense attorney, brings a shocking surprise to Richard when she informs him that the one armed man had died in a fire one week ago. But further research proves that this may have been another one armed man who was still in prison when Helen was murdered.
No good deed goes unpunished when Kimble helps out a stranded motorist who's car has broken down. Lucey Russell, the motorist, gives Richard a place to stay for the evening. But the next morning finds that Lucey's lover has been found dead where her car had broken down. Kimble can prove her innocence but will also cost him his freedom.
a young woman that Richard befriends on a train is mentally ill and is wanted for kidnapping a baby which she believes is her own. To make things worse, she also starts believing that Kimble is her husband. Richard must get the baby back to it's mother without being caught by the authorities.
Kimble's latest escape from Gerard may lead to kidnapping charges when Richard flees a hatchery in which he is working at when Gerard appears, jumping into his car which unknowingly has Gerard's son in the back seat.
Richard is kidnapped by a Korean war veteran who had his legs blown off, mistaking him for Kimble's boss, Mike Pryor, a millionaire whom he was going to hold for ransom.
A sheriff and his deputy come to a struggle when they capture Kimble and then argue over what terms they should turn him over to the authorities.
Richard is given refuge on a farm by Mattie Braydon, a sculptress who has mental instability. While secretly using Kimble as a model, she also has grown fond of him and has no plans of letting him leave and would resort to murder to make sure.
A gas explosion at a roadside diner had cause Richard to have amnesia. While at the hospital he is recognized by a social worker who believes he is innocent while his doctor thinks he is guilty. The one armed man in which Richard was closing in on leaves a message with Gerard, giving Kimble's location.
Kimble is trapped in Puerto Viejo after discovering a plague which is being spread across the area. Richard calls in the alert to the health inspector, then is found out by the local doctor and is also wanted by the local citizens.
A troubled teen passes Richard off as his uncle after he takes refuge in an orphanage.
Richard is on the run again after being named a suspect in a hotel robbery, which was performed by another worker. Having escaped onto a tour bus, Kimble is trapped when a warning is heard by the passengers over the radio and is held captive at gun point.
An industrial accident has Richard trapped underground, but one of the men with him is bent on turning him in and to make things worse, Gerard is awaiting Kimble at the one known exit.
Kimble is arrested by a sheriff in Georgia after catching a ride with Hanes McClure, an escaped criminal who crashes the vehicle into a barricade in his hometown as revenge.
Hallie, a woman in which Kimble is now working with bares a striking resemblance to Helen, his murdered wife. But Hallie's husband knows of their attraction and is jealous of their new relationship.
Richard is hired by Norma to care for her invalid brother Leslie, who was injured in a car accident. What he doesn't realize is that she is planning on murdering Leslie for his insurance money, which will be made easy after discovering that Kimble is wanted by the police and can be framed for the killing.
Richard wanders upon a car accident and uses the tragedy as a way to convince Gerard that he has been killed in the crash.
A sadistic sheriff in Arizona arrests Kimble and uses him as slave labor with a group of other prisoners he has collected. Having witnessed a prisoners murder, Kimble realizes that the whole town is corrupt when the mayor and town council hide the killing as an accident and that he may be next.
Richard goes to work for a wealthy couple as their chauffeur, and witnesses an affair between their daughter and the pool cleaner. But when Kimble is asked to chaperon a birthday party for the daughter, he finds himself in grave trouble when an unruly guest he escorts out recognizes him and threatens to turn him in to the authorities.
A man from Kimble's recent past recognizes him and warns him that he had left behind evidence in a city which made the police believe he had been murdered, and that a man was being held in prison for the killing.
An interesting state of events occurs when both Kimble and Gerard are taken prisoners by a family of backwoods moonshiners. This is Richard's chance to escape, if he can convince the family to hold Gerard hostage and let Kimble go.
Kimble is given protection by a mentally handicapped woman, living alone in an abandoned factory, when he is mistakenly accused of being a serial killer in a small town. Unknown to Richard is the real murderer is also hiding out there.
Richard returns home when he discovers that his murdered wife's family is in financial trouble. Although her sister believes in him, her mother believes he is guilty and her father is being questioned.
Richard uncovers a blackmail plot against his boss at a trucking company, by the widow of a former employee who blames the company for his death. But Kimble discovers that the boss is strapped for cash and plans an insurance scam using one of his rigs.
Kimble is wounded while working as a hospital orderly when he is recognized by the father of a patient who died under his care and is shot down. But after finding out that Richard was not responsible for the child's death, the father wants to confess that he was responsible for Helen's death as an apology.
Richard is mistaken for a former numbers runner who is to testify against a racketeer. They believe he has knowledge of the whereabouts of the man who has run away from a witness protection program and is brought to see his wife. The woman immediately knows that Kimble is not her husband and is asked for her help in escaping.
Richard hides out in a home for the blind after being recognized on TV. One of the residents there is a former policeman who was blinded in the line of duty and forced into retirement. When he recognizes who Kimble is, he believes he can get his job back by capturing Kimble.
Richard is forced to help out three fugitives from justice, two whom are wounded, while aboard a freight train. After one man dies, Kimble is made to help the wound on a vicious killer's leg and then is held hostage in case they need to bargain with the police.
Richard tries to help a group of Hispanic migrant workers after the owner of a citrus farm he is employed on dies unexpectedly, and his racist son takes over the business with plans of firing everyone.
Billy Craft runs a show with wild animals and believes he can get publicity for his act by capturing Richard himself.
Kimble, injured during a police confrontation with an escaped convict, is taken to a prison infirmary for treatment. Though the prison personnel are unaware of his identity, a couple of the inmates there soon recognize him.
Kimble is picked up for questioning when the woman whom he had been seeing is found lying on a road unconscious and badly beaten.
A phony psychic goes on television and states that he can predict Kimble's location.
Donna Taft summons her brother, Richard Kimble, home to Stafford after receiving a letter from an Army captain that he saw a one-armed man fleeing from the Kimble house on the night of Helen Kimble's murder.
Kimble gets caught up in a top-secret government testing of chemical weapons and is pressed into service to care for several injured personnel after an explosion during testing.
Kimble, working as a chauffeur for a rich contractor, accompanies the contractor back to the man's hometown where the employer becomes the target of a killer.
Kimble is hired to drive a woman and her 10 year old driver but is unaware that the woman has abducted the girl from the custody of her ex-husband and that the girl has been exposed to meningitis.
Kimble clashes with a doctor of homeopathic medicine over his treatment methods and it leads to the man's scheming wife discovering his identity.
Kimble gets on a bus bound for nowhere unaware that Lt. Gerard's wife is traveling on the same bus.
Kimble tries to get Gerard's wife aid after she is injured and temporarily blinded in a bus accident but she begins to piece together his true identity.
Working for a trucking company, Kimble becomes involved with the owner's emotionally unstable sister.
Kimble gets a job as a custodian at a youth camp and becomes a suspect when two police officers are found beaten to death.
Kimble is apprehended by a scheming Montana sheriff who sends Gerard away on a wild goose chase when the Indiana lawman arrives on the scene. The reason--the Montanan thinks there's a reward on Kimble and wants it all for himself. It's up to Kimble to persuade the sheriff's galpal to set him free.
Kimble gets involved in the life of a man whose wallet he stole and ends up witnessing the man's murder.
In rural Wyoming, Kimble takes refuge at a small hotel run by a young widow and soon befriends her young son. This friendship soon proves valuable when the police arrive on the scene searching for the fugitive physician.
Kimble travels to a factory town to meet with his dying medical mentor and discovers to his horror that the man has planted a bomb in the local smog producing manufacturing plant.
When a picture of the one-armed man appears in a small-town newspaper it brings both Kimble and Gerard to the scene.
Kimble discovers that his employer's treacherous galpal has betrayed him to the Mob but the man refuses to believe the story.
A policewoman witnesses Kimble being mugged by a trio of delinquents and becomes suspicious of him when he refuses to report the incident.
An accidental killing leaves Kimble on the run from both Gerard and the killer's father who does not want his son implicated.
Kimble is recognized by the uncle of his latest galpal, a retired police detective.
After the death of his father, Kimble travels to Fort Wayne for a meeting with his sister but Gerard and the district attorney who prosecuted the fugitive physician set up a trap.
While working at a swank Beverly Hills hotel, Kimble becomes friends with the galpal of a big time bookmaker and, evoking shades of Born Yesterday, agrees to help her become more "refined." He's unaware that they're being secretly watched by a police detective.
Gerard tracks Kimble to a migrant community in South Texas where they both get trapped in a hurricane.
Kimble takes a job as a chauffeur to a 17 year old prodigal violinist who has grown tired of practicing his trade. Only the youth's demanding manager won't let him quit.
Kimble rescues a Senatorial candidate and his lover from a plane crash and soon comes to wish he hadn't performed the noble deed when the aspiring politico plots to frame him for a murder.
A scientist uses a computer to track Kimble's movements leading to one close call with the law after another for the fugitive physician.
Kimble becomes involved with another wrongfully convicted felon--a recently paroled embezzler who says he's going to kill the man responsible for the crime.
Kimble is recognized by the nephew of his latest galpal who hails originally from Stafford.
In a coastal community, Kimble comes to the defense of a woman believed to be a jinx.
After being shot during a police chase, Kimble takes refuge at a Navajo reservation school in Arizona. Once there, he's befriended by a teacher who removes the bullet but a persistent deputy sheriff is slowly closing in pursuit.
Kimble is the only man who can clear a police officer accused of wrongfully killing a youthful robber but can he do it without his identity being revealed?
Kimble tracks the one-armed man to a seemingly peaceful suburban town that's actually controlled by a gambling syndicate. Not wanting any rocking the boat of his operation, the syndicate boss orders both men out of his town--immediately.
Working as a janitor in an apartment building, Kimble becomes the leading suspect when a woman is bludgeoned to death.
Back in Stafford, the ever persistent Lt. Gerard gets the local newspaper to put up a reward of ten grand for information leading to Kimble's re-capture. This complicates things for Kimble in his newest identity as he's already involved with an autistic girl as well as an escaped killer.
Kimble clashes with a Christian Scientist whose religion forbids the use of antibiotics to help his ailing grandson.
After spotting Fred Johnson's picture in a photograph, Kimble tracks down the one-armed man through the photographer who snapped the photo. The two men scuffle in a chemical plant where Johnson is working. An explosion results which leaves Kimble blinded.
During a labor strike at a winery, Kimble witnesses the son of the winery owner kill a union leader.
Kimble gets involved with a woman and her mentally handicapped brother.
After helping an injured galpal of the one-armed man, Kimble must avoid a trap set at a hospital by Lt. Gerard.
Kimble gets involved in a labor dispute between father and son fishermen.
On the run with the authorities in hot pursuit, Kimble's only avenue of escape is to throw in with a gang of outlaw motorcyclists.
Kimble and an immigrant Hungarian family are taken hostage by an escaped killer.
After Kimble saves his life, a former mobster is determined to repay the debt by killing Lt. Gerard.
Kimble is held hostage at a mountain cabin by three men determined to find out the location of missing stolen loot taken by an accomplice whom Kimble was forced to bring to the cabin.
For the umpteenth time, Kimble gets involved in a father-son conflict. This time it's a small-town sheriff who's son was wounded while attempting a robbery.
A government agent, in pursuit of a fugitive embezzler, also happens upon Kimble, who's working as a deck hand on the embezzler's boat.
A dying building contractor demands that Kimble use his medical skills long enough to keep him alive to finish his latest project.
Hot on the trail of the one-armed man, Kimble meets up once again with Sister Veronica, a nun whom he had encountered two years earlier in Angels Travel Lonely Roads.
Attending a minor league baseball game, Kimble witnesses the kidnapping of a newspaper publisher's daughter.
The one-armed man, now working as a handyman on a college campus, is recognized by an academic friend of Kimble's who tries an experiment to get him to confess.
A man plots to murder his invalid wife and pin the crime on the nearest patsy--Kimble.
An Afro-American deputy is assigned to escort two captured prisoners to jail in Helena, Montana. One is a vicious racist and the other is Dr. Richard Kimble.
Working in a cigar store, Kimble is once again caught up in a father-son conflict and must rely on the son to help him escape from the police.
Recognized by a research doctor in Mexico, Kimble is blackmailed into helping with the man's nefarious experiments.
Cornered in Washington D.C., Kimble is given temporary asylum inside the embassy of an African nation.
Kimble, working as a truck driver, becomes involved romantically with the company's radio dispatcher and soon discovers that she's a convict on a work release program. The you know what hits the fan when her parole officer recognizes Kimble.
Fleeing from a sheriff's deputy into the Oregon hills, Kimble meets up with an ailing eccentric whose only companions are two vicious dogs.
Working as a truck driver in Tucson, Kimble receives word that the one-armed man is being held in a Los Angeles jail so he heads for Tinsel Town. Unfortunately for the fugitive physician, Lt. Gerard is there as well and he sets a trap which Kimble is unable to elude.
Kimble faces the end when he is re-captured by Gerard in Los Angeles and taken back to Stafford. But unknown to both men, the one-armed Fred Johnson has also arrived in Stafford and he proceeds to blackmail a prominent citizen of the town who knows what really happened on the night Helen Kimble was murdered.