When the girls thwart Mojo Jojo's attempt to steal Chemical X, he invents an evil video game to control their minds and bodies.
Prime Apes: Back when Mojo tried use primates to try to take over the world, there was Mopey Popo, who didn't didn't get his due. But now he's back and wants to be evil!
Coup D'Ete: The Professor is trying out his new car, but the car is taking him away from the Powerpuff Girls.
Make Zen To Me: After reading a fortune cookie, Buttercup goes on a journey to find inner peace.
Say Uncle: The Professor at first tells the Powerpuff Girls all about Eugene, his younger brother and how he was so wild back in the day and when Eugene is coming to Townsville, the Powerpuff Girls mistake him for a monkey.
Guest Stars: Catherine Cavadini
as Woman #2 | Tara Strong
as Julie Bean, Mother, Baby | Dee Bradley Baker
as Chap #1, Messenger, Scrawny Guard, Beastman, Eugene | Jennifer Hale
as Mary | Jim Cummings
as Doctor, Fuzzy Lumpkins | Tom Kane
as Snooty Man | Tom Kenny
as Chap #2, Chubby Guard, Man, Dude #1 | Elizabeth Daily
as Woman #1, Dude #2 | Keone Young
as Monk, Server
Reeking Havoc: The Professor wants to win the 2nd Townsville Annual Cook-Off and the Powerpuff Girls help by putting chemical X in the chili to make it special. The Professor wins but the chili has a surprise on the people of Townsville.
Live and Let Dynamo: In this episode, Dynamo returns but is now destroying Townsville. Who is controlling Dynamo?
Guest Stars: Catherine Cavadini
as Woman | Kevin Michael Richardson
as Gas Monster, Man #1, Washer, Dog, Man #3 | Jeff Bennett
as Homie #1 | Jennifer Martin
as Ms. Bellum | Rob Paulsen
as Homie #2 | Roger L. Jackson
as Butch, Crowd Member #7 | Tom Kane
as Construction Guy, Crowd Member #5 | Tom Kenny
as Peace Man, Guy, Man #2, Snake, Lil' Arturo
Oops, I Did It Again: The Professor tries to do something on purpose because his experiments that were successful were just accidents.
Mo' Linguish: As part of his community service, Mojo Jojo begins teaching English at the Learning Annex. Soon, everyone starts to talk like Mojo!
Guest Stars: Tara Strong
as Beatrice | Elizabeth Daily
as Betty | Jennifer Martin
as Ms. Bellum | Jeff Bennett
as Ace, Grubber, Harouk | Jennifer Hale
as Lady, Nadia | Roger L. Jackson
as Ernst, Robber, Ming | James Arnold Taylor
as Fella, Man, Phillipe, Cop | Tom Kane
as Judge, Vendor | Tom Kenny
as Jimmy, Arturo, Enrique
There's a new villain named Mask Scara who is defacing all of the posters of Townsville. Mask Scara gives people horrible makeovers that are almost impossible to take off. Now the Professor must find the cure for these makeovers and also Blossom must stop Mask Scara.
Little Miss Interprets: The Powerpuff Girls think that the Professor is making new little girls when they hear the Professor trying to make something out of sugar, spice and everything nice.
Night Mayor: The Powerpuff Girls go into the Mayor's dreams when he keeps having the same dream over and over again but never sees the end.
Custody Battle: The Rowdyruff Boys are back on Father's Day and Mojo Jojo discovers that Him is their father and made them much better than Mojo did. So, Him and Mojo go in a competition to see who is the better dad.
The City Of Nutsville: Bubbles is not allowed to talk for a week when she gets stung in the mouth by a bee.
The Gangreen Gang is committing crimes that are brilliant. They have to steal magical items for Sedusa so she can get revenge on the Powerpuff Girls for cutting her hair.
That's Not My Baby! : The Powerpuff Girls try to look for a baby's mother, but they couldn't find her. They decide to care for the baby themselves and prove to the Professor that they can own a hamster.
Simian Says: Mojo Jojo kidnaps the Narrator and decides to take over as narrator and control the Powerpuff Girls' actions.
Sun Scream: The Powerpuff Girls' super powers are weakened because they got sun-burned.
The City Of Frownsville: Everyone is happy when a carnival arrives in Townsville, but Lou Gubrious, a man who keeps shedding tears, sets out a crying ray on Townsville. Now the town will be flooded, unless someone saves the day.
Professor Utomium sends little girls with super powers called the Steamypuff Girls (who look a lot like the Powerpuff Girls) to save the western version of Townsville from Mojo the Kid.
Crazy Mixed Up Puffs: The Powerpuff Girls literally as one must stop Mojo Jojo from destroying Townsville.
Mizzen In Action: Captain Crack McGraigen and his crew go forward in time to the present. They find chemical X and now they have super powers.
What's The Big Idea: The Powerpuff Girls try to stop Mojo from taking over Townville.
Roughing It Up: The Professor and the Powerpuff Girls go on an old-fashioned vacation to the Townsville Swamp, but the trouble is that Fuzzy Lumpkins and his nephews are at the Townsville Swamp too.