Sarah, a successful children's book editor, must go to her sister for help when she learns she is unable to have children. Sarah asks CoCo, her estranged and free-spirited younger sister, to be the surrogate mother to her child. Can the sisters put aside their differences in order to bring a child into the world?
Coco decides to help her sister, packs up her belongings and moves into Sarah's loft. Meanwhile, Sarah must deal with a surprise visit from her mother and father, who both take a turn for the worst.
Sarah sets her sights on signing a 15-year-old child prodigy in order to get the rights to his new book and must go to great lengths to make a good impression the the boy. She tries to entice him with Knicks tickets, but soon finds that bed and bath items are more up his alley. Meanwhile, Sarah and Coco go to Coco's first visit in a long time to the gynecologist where Sarah finds out some of her sister's greatest fears.
Talia comes over visit Coco unexpectedly one too many times, leading Coco to get out of the loft and find a job. She lands a job walking a neighbor's dog, which gives her the idea to start a dog-walking empire. However, her idea falls apart when Sarah reports the neighbor to the co-op board for violating the no animal rule in the building. Later, feeling guilty, Sarah spends the night with Marcus, breaking one of their cardinal rules.