Chalkboard: None

Couch: Repeat of the couch gag from "Don't Fear the Roofer" where a human tries to complete a Simpsons puzzle, but mixes up Homer's and Maggie's heads (only in this version, the person completing the puzzle yells, "D'oh!" when the heads are mixed up and giggles when the puzzle is corrected).

Sea Captain: Arr yes, the ship that brought prostitutes to America.
Lisa: Not prostitutes, Protestants.
Sea Captain: Now, who's been naive?!

Marge: (asked after her name in the Mayflower story) Constance Prudens Chesterty Goodfaith.
Homer: Doh!
Marge: My friends call me Marge.
Homer: Oh?
Marge: Marge Obedience Temporance Sexwont.

Lovejoy: Lord, we thank you for the many ways you show your love. The sun which bakes our lips to the point of bleeding. (laughs) And your hilarious idea to surround us with water that would kill us, if we drink it.

Moe: Anyways, I just wanted to let'u know, that I'm throwing a little party tonight. To celebrate that only half of us've died so far.

Homer: Beer? I thought you guys didn't drink on the Gayflower.

Flandish: Horseplay. Rough-housing. Horse-housing?!

Homer: Land Ho!
Marge: What did you call me?

Lisa tries to convince everyone that the ability to add two-digit numbers isn’t witchcraft, but the crew doesn’t listen. This seams to be a reference to the Salem Witch Trials, in which several people (around twenty) were sentenced to death without any real evidence. Read more about the trials in the wikipedia article.

The restaurant name The Frying Dutchman is an obvious parody of the Flying Dutchman, a ghost ship that is cursed to sail the seven seas forever. Read more about legend in the wikipedia article.

Lisa’s story takes place on the Mayflower, whose occupants established the first permanent English settlement, Jamestown. Read more about the settlers ship in this wikipedia article. Read more about the Jamestown Settlement in that wikipedia article.

This episode's title is an adaptation of “The Greatest Story Ever Told”, a 1965 Biblical epic film produced and directed by George Stevens that revolves around the life and death of Jesus that features an all star cast including Charlton Heston, Max von Sydow, Dorothy McGuire, Jose Ferrer & Telly Savalas

The couch gag (where The Simpsons are a puzzle) is a repeat of the one from "Don't Fear the Roofer" (only in the version on "Don't Fear the Roofer", the person completing the puzzle didn't yell "D'oh!" when he mixed up Homer's and Maggie's heads, nor did he giggle when he corrected the mistake).